Epidemija koronavirusa (Covid-19 / SARS-Cov2) - dnevne aktuelnosti iz zemlje i sveta

[Sunshine State]

Samo da dodam - moja kompanija ima mnoooogo vise koristi od ispitivanja Pfizerove vakcine - da nismo radili  na njoj, vraga bismo kupili drugu, vecu kompaniju od nas.

 

Finansijski, meni vise odovara da se ispituju novi lekovi.

Licno, najsrecnija bih bila kad bi rekli - neki, vec postojeci lek, ciji safety panel vec poznajemo, radi posao (to uopste ne mora biti ivermectin)

 

 

[wwww]

2 hours ago, Beonegro said:

Izdali su ispravku

 

TOKYO, Jan 31 (Reuters) - Japanese trading and pharmaceuticals company Kowa Co Ltd (7807.T) on Monday said that anti-parasite drug ivermectin showed an "antiviral effect" against Omicron and other coronavirus variants in joint non-clinical research.

The company, which has been working with Tokyo's Kitasato University on testing the drug as a potential treatment for COVID-19, did not provide further details. The original Reuters story misstated that ivermectin was "effective" against Omicron in Phase III clinical trials, which are conducted in humans.

 

Mada valja ovo pustiti s vremena na vrijeme, da se vlasnici rogova među nama i oni ponekad obraduju.

 

31 minutes ago, shonke said:

 

"showed an "antiviral effect" against Omicron and other coronavirus variants in joint non-clinical research."

 

Ovo je isto kao kad bi mi utvrdili da ivermectin ima efiksanost 100% jer je jedan pacijent @Akiro pretekao prošle godine a drugi (gđa Akiro) se nije ni razbolela.

 

U onom tekstu kaže i sledeće: "The use of ivermectin to treat COVID-19 is currently being investigated in a UK trial run by the University of Oxford. The researchers said on Monday that it was still under way and they did not want to comment further until they have results to report."

 

Kad ovi zvanično nešto objave, imaćemo kome da verujemo.

 

nista ja nisam komentarisala da li je to lek ili nije, sve lepo pise u tekstu - ko otvori i procita.

 

moji smajliji su iskljucivo bili zbog samog ivermektina kao leka koji se ispituje za potencijalnu upotrebu protiv ovog corona virusa.

[erwin]

[Sunshine State]

1 hour ago, shonke said:

U onom tekstu kaže i sledeće: "The use of ivermectin to treat COVID-19 is currently being investigated in a UK trial run by the University of Oxford. The researchers said on Monday that it was still under way and they did not want to comment further until they have results to report."

 

Ne samo tamo, navedoh gore da ima cak 83 klinicke studije

 

Primera radi, kad je krenula pandemija, bilo je reci i o nekim drugim lekovima (statini, fluoxetine,....), pa ne vidim podugacku listu studija koje su nastavile da istrazuju ove lekove kao potencijalne lekove za covid - fluoxetine/Covid ima 4 klinicke studije; atorvastatin/covid ima 10 studija

 

Edit: spomenuo si Akira - ima jos jedan forumas, cija je zena koristila, a on nije - on je zavrsio u bolnici, ona prosla ok; zanima me da li bi i on, kad pogleda unazad, uzeo ivermectin, kad zna kako je on prosao, a kako ona?

Naravno, ne postoje dva ista slucaja na svetu, i ne znaci da bi njemu imalo pomogao

 

Ja sam u novembru 2020. kad sam izgubila miris, radila nesto sto moj muz nije, prosto ga mrzelo..... meni se posle 7 dana vratio miris, i nakon toga se kompletno povratio. Moj muz i dan-danas ima problema s culom mirisa i cesto kaze:"Mozda je trebalo i ja da uzmem isto sto i ti"

 

 

 

Edited February 2, 2022 by Sunshine State

[erwin]

U celoj 2020. - 84 miliona zvanično detektovanih slučejeva koronavirusa u svetu, u zadnjih mesec dana - 90 miliona (uglavnom omikron i ostaci delte).

 

 

SAD najgore prolazi od većih razvijenih zemalja kad je omikron u pitanju.

 

 

Vakcine rade i protiv zaražavanja omikronom, a protiv hospitalizacije su odlične.

 

 

 

 

Zbog reinfekcija se u Engleskoj umire ubedljivo najviše dosad.

 

 

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1051898/UKHSA-technical-summary-update-February-2022.pdf

Edited February 2, 2022 by erwin

[erwin]

  

Quote

Dr Aneta Jovanović, načelnica Pedijatrijske službe Doma zdravlja Palilula, kaže za RTS da, zbog omikrona, imaju i do 400 pregleda dnevno.

"Imamo decu i predškolskog i školskog uzrasta kojih je najviše, oko 40 do 60 odsto. Sreća je da je klinička slika laka, da se radi o simptomoma prehlade. Deca se žale na bol, na grebanje u grlu, na zapušenost nosa, praćeno je temperaturom. Neka deca kašlju malo nadražajno, ali za tri do četiri dana deca budu dobro", navodi Jovanovićeva.

Ističe da je većina dece koja se testira, oko 90 odsto, pozitivna.

"Radi se o lakšoj kliničkoj slici, komplikacije su jako retke za sada. Ako roditelji primete da dete dobije temperaturu, bol u grlu, zapušenost nosa, da dete izoluju i testiraju ga. Terapija je simptomatska - da obaraju temperaturu, da daju paracetamol ili brufen, kapi za otpušavanje nosa, toaleta nosa i što više tečnosti", dodaje Jovanovićeva.

Napominje da se deca testiraju da bi znali da li bi trebalo da budu u izolaciji.

"Imamo i druge simptome, respiratorne i stomačne tegobe kod dece, s tim što se radi u većini slučajeva o omikronu. Imali smo ih par koja su negativna, a imaju simptome koji su slični gripu, ali ne radimo test za grip, pa ne možemo da ga detektujemo", ističe dr Jovanović.

Prema njenim rečima, vakcinacija je stala.

"Apelujem na roditelje da decu koja imaju oboljenja kao astma, dijabetes, hronična neurološka oboljenja da ih dovedu i vakcinišu, jer je vakcina bezbedna i štiti dete od daljih komplikacija", kaže Jovanovićeva.

Crvena zona dečje kovid ambulante DZ Palilula za decu radi od 7 do 20 časova, a vikendom od od 8 do 18 časova.

 

Quote

Od petka ceo KBC "Dr Dragiša Mišović" u kovid sistemu

Zamenik direktora KBC "Dr Dragiša Mišović" Predrag Savić kaže za RTS da će od petka u kovid sistem biti uključen i A blok ove zdravstvene ustanove.

 

https://www.rts.rs/page/stories/sr/Коронавирус/story/3134/koronavirus-u-srbiji/4684789/koronavirus-podaci-zarazeni-srbija.html

[erwin]

 

 

Edited February 2, 2022 by erwin

[erwin]

 

 

Dobar članak Sajensa o varijanti BA.2.

 

Quote

Sudden rise of more transmissible form of Omicron catches scientists by surprise
“Sister” of original may extend Omicron surges, but no evidence yet it causes more severe disease

On 7 December 2021, as the Omicron variant of the pandemic coronavirus began to pummel the world, scientists officially identified a related strain. BA.2 differed by about 40 mutations from the original Omicron lineage, BA.1, but it was causing so few cases of ­COVID-19 that it seemed a sideshow to its rampaging counterpart.

“I was thinking: ‘BA.1 has the upper hand. We’ll never hear again from BA.2,’” recalls Mark Zeller, a genomic epidemiologist at the Scripps Research Institute. Eight weeks later, he says, “Clearly that’s not the case. … I’m pretty sure [BA.2] is going to be everywhere in the world, that it’s going to sweep and will be the dominant variant soon in most countries if not all.”

Zeller and other scientists are now trying to make sense of why BA.2 is exploding and what its emergence means for the Omicron surge and the pandemic overall. Already a U.K. report issued last week and a large household study from Denmark posted this week as a preprint make it clear BA.2 is inherently more transmissible than BA.1, leaving scientists to wonder which of its distinct mutations confer an advantage.

But so far, BA.2 does not appear to be making people sicker than BA.1, which itself poses less risk of severe disease than variants such as Delta and Beta. In Denmark, where by 21 January BA.2 accounted for 65% of new COVID-19 cases, “We see a continuous, steep decline in the number of intensive care unit patients and … now a decrease in the number of hospital admissions related to SARS-CoV-2,” says Tyra Grove Krause, an infectious disease epidemiologist at the country’s public health agency. In fact, the Danish government is so confident the variant won’t cause major upheaval that it lifted almost all pandemic restrictions on 1 February.

Still, some scientists predict BA.2 will extend Omicron’s impact. “I would guess we’ll see [BA.2] create a substantially longer tail of circulation of Omicron than would have existed with just [BA.1], but that it won’t drive the scale of epidemics we’ve experienced with Omicron in January,” computational biologist Trevor Bedford of the Fred Hutchinson Cancer Research Center tweeted on 28 January. In South Africa, BA.2 already may be stalling the rapid decline in new infections seen after the country’s Omicron wave peaked in December 2021.

Although BA.2 represented less than 4% of all Omicron sequences in the leading global virus database as of 30 January, it has been identified in 57 countries, with the earliest documented case dating to 17 November in South Africa. It likely now dominates in India, according to Bijaya Dhakal, a molecular biologist at the Sonic Reference Laboratory in Austin, Texas, who examined sequence data uploaded from eight large Indian states. In the United Kingdom, the proportion of likely BA.2 cases doubled from 2.2% to 4.4% in the 7 days that ended on 24 January.

In the United States, the Centers for Disease Control and Prevention is not yet tracking BA.2 separately. But Bedford estimates it accounted for 7% of new U.S. cases as of 30 January, up from 0.7% on 19 January. “In each country and across time, we see that the epidemic growth rate of Omicron BA.2 is greater than Omicron BA.1,” he says.

The report last week from the UK Health Security Agency (UKHSA) backs up that assessment in England, finding BA.2 was spreading faster than BA.1 in all regions where enough data were available to make an assessment. UKHSA data also show that in late December 2021 and early January, transmission was higher among household contacts of BA.2 cases, at 13.4%, than in contacts of other Omicron cases (10.3%).

The study from Denmark, which sequences the virus from virtually every person who gets COVID-19, paints a more dramatic picture. In households where the first case was BA.1, on average 29% of other people in the household became infected. When the first case was BA.2, 39% of household members were infected.

Omicron was already known to have mutations that help it evade antibodies, but the Danish researchers also found that BA.2 may be even better at dodging vaccine-induced immunity: Vaccinated and boosted people were three times as susceptible to being infected with BA.2 as with BA.1. Vaccinated but unboosted people were about 2.5 times as susceptible, and unvaccinated people 2.2 times as susceptible. Early U.K. data, however, showed vaccinated people, if boosted, had about the same level of protection against symptomatic infections with BA.1 or BA.2—63% and 70%, respectively.

In one hopeful and unexpected finding from Denmark, those who were vaccinated or vaccinated and boosted passed on BA.2 to household members less often, relative to BA.1. The same didn’t hold for unvaccinated people, who passed BA.2 to their household contacts at 2.6 times the rate they passed BA.1.

Much as scientists a few weeks ago wondered whether a previous infection with Delta or another variant would protect people from Omicron overall, some are now looking for data on whether Omicron’s first surge created a shield against BA.2. “To what extent does a BA.1 infection protect you against reinfection with BA.2?” Zeller asks. “From what I have seen in Denmark, it’s not going to be 100%.”

Scientists are also probing the variant’s ability to dodge vaccine-induced antibodies in lab dish studies. And drugmaker GlaxoSmithKline is testing its monoclonal antibody, sotrovimab, made with Vir Biotechnology, against BA.2 in lab studies. It’s the only widely authorized antibody that still thwarts BA.1.

Scientists note BA.1 and BA.2 are about as far apart on the evolutionary tree as earlier variants of concern—Alpha, Beta, and Gamma—are from each other (see graphic, below). Some even think BA.2 shouldn’t even be considered Omicron. “I hope in the near future that BA.2 gets its own variant of concern [label] because people assume it’s very similar which it’s not,” Zeller says.

BA.2 doesn’t have all of the mutations that help BA.1 avoid immune detection, but it has some its sibling doesn’t. Thomas Peacock, a virologist at Imperial College London, notes that most of the differences are in an area of the spike protein, called the N-terminal domain (NTD), that houses antibody targets. “What we don’t know is: Just because there are changes, are they changes that actually do something?” says Emma Hodcroft, a molecular epidemiologist at the University of Bern.

But one NTD difference—a deletion at amino acids 69 and 70 that is present in BA.1 and not in BA.2—could give researchers a tool for monitoring the spread of the up-and-coming Omicron strain. Certain SARS-CoV-2 polymerase chain reaction tests detect three genetic sequences of the virus, but the mutation in BA.1’s NTD gene eliminates one of those targets. Polymerase chain reaction tests pick up all three targets in BA.2, providing a proxy for distinguishing the Omicron strains if there is no full virus sequence.

How the sibling strains were born is also preoccupying scientists. Viral evolution in a single immunocompromised patient is one theory, says Andrew ­Rambaut, an evolutionary biologist at the University of Edinburgh. “It’s possible that long-term infection could produce quite a lot of diversity within a single individual. It could be compartmentalized. So different variants living in different parts of the body.” Both Omicron strains could have also evolved in animals infected with human-adapted SARS-CoV-2, then spread back into people.

Why BA.2 is emerging only now is one more mystery, Hodcroft says. She speculates that a factor as simple as which Omicron caught an earlier flight out of South Africa, where both strains were first identified, may be the explanation. “BA.2 may have just been trapped for a little bit longer. But when it did finally get out and start spreading it started to show that it can edge out its big sister.”

https://www.science.org/content/article/sudden-rise-more-transmissible-form-omicron-catches-scientists-surprise

[urosg3]

19 minutes ago, erwin said:

 

 

Bio sam ubeđen da je Izrael bolji  sa vakcinacijom, i da je takoreći država za uzor. Šta im se desilo?

[erwin]

Realno ne stoje baš tako loše kao SAD. 27% onih sa dvema dozama još nije primilo treću, dok najstariji uveliko primaju četvrtu. Topol malo izvrće činjenice ne spominjući da je Izrael zemlja sa daleko mlađim stanovništvom od SAD.

 

 

https://datadashboard.health.gov.il/COVID-19/general (prevod: Google Translate)

Edited February 2, 2022 by erwin

[Ridji]

On 2/1/2022 at 5:10 PM, wwww said:

 kolko vam je proslo od poslednje vakcine? (pretpostavljam bustera i da je to bio Fajzer) mozda i to igra ulogu.

Ja sam primio tri Sputnjika, treći je bio 4. novembra. Supruga je istog dana revakcinisana Fajzerom.

 
Padaju mi na pamet dva razloga da sam lošije prošao od nje, prva da je ona negde uhvatila manju količinu virusa a da se virus kod nje namnožio pa sam ja zato dobio više virusa, spavajući sa njom i normalnim funkcionisanjem. A drugi je da su uticali moji očajni sinusi.

[zoe Bg]

17851/36874/61

 

Na respiratoru 166

 

U bolnicama 3962

[urosg3]

15 minutes ago, erwin said:

Realno ne stoje baš tako loše kao SAD. 27% onih sa dvema dozama još nije primilo treću, dok najstariji uveliko primaju četvrtu. Topol malo izvrće činjenice ne spominjući da je Izrael zemlja sa daleko mlađim stanovništvom od SAD.

Ne baš malo ili marginalno. 

[implant]

Dobro, hoćemo li mi koji upravo preležavamo Omikron (i oni koji su ga već preležali) biti imuni na ove njegove varijante, ili jok?

[urosg3]

6 minutes ago, implant said:

Dobro, hoćemo li mi koji upravo preležavamo Omikron (i oni koji su ga već preležali) biti imuni na ove njegove varijante, ili jok?

Daj prvo raport, dnevni izveštaj!

[implant]

3 minutes ago, urosg3 said:

Daj prvo raport, dnevni izveštaj!

 

Nemam ništa novo da prijavim. Temperature nema, povremeno mi se začepi nos (ali ne skroz), naročito ujutro kada ustanem. Povremeno mi se slije malo šlajma iz nosa u grlo i to je to. Nadam se da će tako i ostati, sutra idem na kontrolu pa ćemo da vidimo...danas je 7. ili 8. dan simptoma, zavisi kako računaš prvi, da li kao prvi ili nulti.

[Sunshine State]

11 minutes ago, implant said:

Dobro, hoćemo li mi koji upravo preležavamo Omikron (i oni koji su ga već preležali) biti imuni na ove njegove varijante, ili jok?

 

Hocemo, ne brini!

 

 

[urosg3]

1 minute ago, implant said:

 

Nemam ništa novo da prijavim. Temperature nema, povremeno mi se začepi nos (ali ne skroz), naročito ujutro kada ustanem. Povremeno mi se slije malo šlajma iz nosa u grlo i to je to. Nadam se da će tako i ostati, sutra idem na kontrolu pa ćemo da vidimo...danas je 7. ili 8. dan simptoma, zavisi kako računaš prvi, da li kao prvi ili nulti.

Ok, sad si naš 🙂

[implant]

2 minutes ago, urosg3 said:

Ok, sad si naš 🙂

 

Kako to? Misliš da je prošlo?

[Sunshine State]

Just now, implant said:

 

Kako to? Misliš da je prošlo?

 

Pa dokle bi ti da traje?!

[implant]

6 minutes ago, Sunshine State said:

 

Hocemo, ne brini!

 

 

 

Iz tvojih usta u Božje uši, da se malo i ja opustim.

5 minutes ago, Sunshine State said:

 

Pa dokle bi ti da traje?!

 

Pa valjda dok ne budem negativan na testu? Prekjuče radio kućni, pozitivan kao prvog dana. I još ovaj post-nazalni drip...sa njime muku mučim još od onog gadnog gripa iz 2018., mada se sada manje sliva.

[urosg3]

3 minutes ago, implant said:

 

Kako to? Misliš da je prošlo?

Uživaj, sad će da te poteraju da rmbačiš nešto, ovako to krene, zvoni telefon:

X. E ćao kako si?
Ja: Temperature nema, povremeno mi se začepi nos (ali ne skroz), naročito ujutro kada ustanem. Povremeno mi se slije malo šlajma iz nosa u grlo i to je to. Nadam se da će tako i ostati, sutra idem na kontrolu 
X: Ma super je to, nego jel` bi mogao samo..., ali i da vidiš... a na ovom serveru ... a mogao bi i da instaliraš onome ... Ono već kad nemaš temperaturu. A kad smeš da izlaziš? Već su zvali iz ... a znaš da treba da odeš u ... njima ne radi... a možeš i da svratiš posle do ...
Ja: izvesni pas i mater od X

 

[Sunshine State]

Pa i zvanicno je izolacija 7 dana - koliko bi se vi razvlacili po kuci?

Edited February 2, 2022 by Sunshine State

[implant]

9 minutes ago, urosg3 said:

Uživaj, sad će da te poteraju da rmbačiš nešto, ovako to krene, zvoni telefon:

X. E ćao kako si?
Ja: Temperature nema, povremeno mi se začepi nos (ali ne skroz), naročito ujutro kada ustanem. Povremeno mi se slije malo šlajma iz nosa u grlo i to je to. Nadam se da će tako i ostati, sutra idem na kontrolu 
X: Ma super je to, nego jel` bi mogao samo..., ali i da vidiš... a na ovom serveru ... a mogao bi i da instaliraš onome ... Ono već kad nemaš temperaturu. A kad smeš da izlaziš? Već su zvali iz ... a znaš da treba da odeš u ... njima ne radi... a možeš i da svratiš posle do ...
Ja: izvesni pas i mater od X

 

 

Šta ti je, pa ja sve vreme radim od kuće. Malo nas je u sektoru pa ne bih da ostali izginu ako ja već nemam neke jake simptome.

Edited February 2, 2022 by implant

[urosg3]

5 minutes ago, Sunshine State said:

Pa i zvanicno je izolacija 7 dana - koliko bi se vi razvlacili po kuci?

To za Omikrona, za Deltu je bilo 14 dana. A za Wuhanski original - 28 dana. De poslušah da nosim masku e 28 dana!

Edited February 2, 2022 by urosg3