Covid-19 / SARS-Cov2 - naučne/medicinske informacije i analize

[Clash]

Valjda ce kod nas ici lakse, posto mi vec imamo mentalitet krda, samo da dobacimo do tog imuniteta krda.

[Eddard]

Podcast Prof. Drostena od juče je doneo par interesantnih i korisnih informacija, pre svega što se tiče lekova, pa ću probati da prenesem najbitnije delove:

 

• Testovi na antitela virusa, bilo da je u pitanju klasični ELISA test u laboratorijama, ili oni koji polako dolaze na tržište ("lateral-flow" iliti kao testovi za trudnoću) su dobri da bi se videlo da li je neko preležao infekciju, jer se antitela grade tek nakon 10ak dana od početka infekcije. Za sveže slučajeve su neupotrebljiva, tu jedino detekcija virusa u grlu/plućima/stolici ima smisla (PCR).
• Raširenost imunoloških testova je još uvek mala, samo vodeće laboratorije imaju ELISA testove, tako da će proći nekoliko nedelja do dva meseca dok to ne bude dostupno praktično da u svakoj ordinaciji lekara se uzme uzorak, pošalje u lokalnu laboratoriju i brzo dobije rezultat. Dakle, u sadašnjem trenutku nisu nešto na šta treba obraćati mnogo pažnju, kasnije da se proceni koliki je procenat imunizovanih, pogotovo kod zdravstvenih radnika će imati smisla. 
• Dinamika infekcije je takva da virus u prvoj nedelji može dobro da se dokaže u ždrelu, pa polako silazi u pluća. Već od početka te prve nedelje može da se desi da brisom iz ždrela se više virus ne detektuje jer je u maloj koncentraciji, ali i dalje može aspiratom ili ispljuvkom iz pluća, kao i u stolici. Problem je đto pacijenti tek u drugoj nedelji bolesti dolaze u bolnicu, kad se i klinička slika pogoršava. Tu pomaže onda CT pluća, kao i pomenuti uzorak sputuma. 

• Lekovi:
  • Remdesivir - lek protiv Ebole,  takođe RNK virusa, koji deluje tako što inhibira enzim RNK-Polimerazu, koja praktično multiplikuje virus u ljudskoj ćeliji, a koju ima i SARS-CoV-2. Lek je dobro poznat, deluje i protiv Coronavirusa u ćelijskoj kulturi i na životinjskim modelima, ali... lek se daje samo pacijentima kojima već treba kiseonik i koji ulaze u kritičnu fazu bolesti. Problem je u tome što je to direktna antivirusna supstanca koju zapravo treba davati ranije. Zato što virus napada respiratorni trakt u prvoj nedelji bolesti. U drugoj nedelji bolesti, gde se ona pogoršava, već imamo kombinaciju imunoloških i virusnih efekata koji deluju u plućima. To sugeriše da u ovoj kasnijoj fazi se ne može mnogo uraditi ako samo dajete nešto protiv virusa. Tada mora da se deluje i protiv protiv prekomernog imunog odgovora (cytokine-storm). Ovo se odnosi i na Remdesivir i na druge supstance koje imaju direktan uticaj na virus. Ono što je dobro - mehanizam je poznat, lek poznat, deluje na virus, pa bi mogao imati efekta, ali problem je u tajmingu davanja.
  • Chloroquine - takođe poznat lek koji se koristi protiv malarije, reumatoidnog artritisa itd. Za njega se zna da deluje tako što menja jonski sastav ćelije, tj. pH i time sprečava replikaciju ne samo Coronavirusa već i svih drugih u ćelijskim kulturama, znači jedno nespecifično dejstvo na sve i svašta, samim tim i mnogo neželjenih efekata. Ponovo se osvrnuo na francusku studiju opet rekavši da je poprilično manjkava i da on ne očekuje da ovaj lek igra bilo kakvu ulogu protiv Coronavirusa, pogotovo ne da bude čarobna pilula koja će pacijente da izleči, ako i bude efekta biće minorni, ali potrebne su bolje studije. 
  • HIV lekovi (Lopinavir + Ritonavir) - inhibitori enzima proteaze koja ima ulogu da već napravljen virusni protein isecka u gradivne delove virusa - ukratko, prvi rezultati za Coronaviruse nisu obećavajući, najverovatnije jer je proteaza drugačija nego kod HIV-a. To je pokušano čisto iz očaja, ajde da probamo, ali bez rezultata. 
  • Favipavir - takođe inhibitor RNK Polimeraze, u nekim zemljama se koristi protiv Gripa (u Japanu može da se kupi). Ovaj lek je lično Prof. Drosten u vreme epidemije SARS i MERS u laboratoriji testirao i nije pronašao nikakav efekat na ćelijsku kulturu. Ali lek se trenutno daje u Kini sa određenim pozitivnim rezultatima i rađena je studija koja pokazuje, da ako se da u ranoj fazi, ima statistički značajnu razliku u kliničkoj slici, tj. dovodi do poboljšanja. U grupi kritično bolesnih nije bilo efekta. Obećava, mora da se još testira, potrebne su studije, ova jedna nije dovoljna za definitivan zaključak. On je lično iznenađen zaključcima studije i skeptičan, ali može da bude značajno. 
  • Interferoni - ukratko, ne. Ako se daje baš baš rano onda može imati efekta ( a pritome su neželjena dejstva velika), a ako se da kasno onda može da deluje kontraproduktivno i opasno. 
  • Camostat - lek koji je u upotrebi kod hroničnog pankreatitisa, supstanca je koja sprečava ulazak virusa u ćeliju (trenutno ispitivanja vrše naučnici u Göttingenu sa Drostenom), tako što inhibira ćelijski enzim transmembransku proteazu koja pomaže virusu, odnosno potrebna je virusu da ovaj uopšte uđe u ćeliju (virus se razmnožava samo u ćeliji, znači mora u nju). U ćelijskim kulturama deluje, ali sad moraju da se preskoče regulative i studije na životinjama da bi se ispitalo da li deluje i in vivo i sa tim trenutno počinju, pa ćemo videti.

 

• Još jednom, prirodni tok infekcije:
  • U početku virus prelazi na sve sluzokože i sve organe respiratornog trakta. U gornjem delu prvo (ždrelo), a zatim dole u pluća (prva nedelja). U drugoj nedelji dolazi imuni sistem i pokušava se osloboditi virusa. Ovaj imuni odgovor, na prvi pogled, je naravno dobar. Ali na drugi pogled, ta reakcija takođe može biti preterana i može biti takva da mora da ukloni određeno zaraženo tkivo. Ne postoji drugi način da se oslobodite virusa. Ovo stvara, na primer, upalu, koja se zatim vidi na snimanju, CT-u, u plućima. Ako se nastavi, onda se u teškim tečajevima može dogoditi da određene imune reakcije postanu nezavisne od virusa. A virus je već relativno dobro eliminisan, još nije potpuno nestao, ali verovatno se više ne razmnožava aktivno. Ali procesi upale se nastavljaju. A to je otprilike treća sedmica bolesti i dalje. I tu antivirusni lekovi ne pomažu, već bi trebalo da se daju u prvoj nedelji infekcije. A prva nedelja je po pravilu blaga, tek na kraju nje ide ili u dobrom ili u lošem pravcu. A s obzirom da se ne zna u kom će pravcu bolest i da kod ogromne većine ide u dobrom pravcu, onda ne mogu ni ovi lekovi tek tako da se daju jer nisu potrebni, pa bi to bilo eksperimentalno davanje leka bespotrebno, off label upotreba. Etički problem. 

 

 

Edited March 27, 2020 by Eddard

[wwww]

Par zanimljivosti iz danasnjeg podcasta Prof Drostena (pastajem fan, a i sve cu vas preobratiti u fanove, kakvi fudbalski timovi, kakvi bakraci )

 

- Pitali ga da li je sasvim iskljuceno da se corona virus pojavio mnogo ranije u Evropi (u decembru). Kaze da do sada nije nasao nikakav dokaz za to da je corona bila u Evropi pre sredine januara (cak su ispitali par slucajeva kad su im se javili ljudi koji su tvrdili da su krajem prosle godine bili u kontaktu s nekim saradnicima iz Kine, pa se potom mnogi u firmi malo zesce razboleli od neke vrste gripa - uradili su testove i nisu nasli nikakav dokaz da su ovi bili zarazeni corona virusom)

 

- Misli da se corona previse rasirila i da nece u jednom trenutku samo nestati, vec da ce se, posle dostizanja 60-70% zarazenih i smirenja pandemije, ostatak naroda postepeno zaraziti i prelezati ga. (sto ce reci: ne mozemo umaci coroni)

 

- O simptomima:

Tipicni simptomi su suv kasalj i temperatura; bol u grlu ne mora nuzno da se javi.

U principu se ne javlja kijavica kada se cedi iz nosa; neki pacijenti su opisali simptome upale sinusa (bol i pritisak u sinusima).

Kod nekih pacijenata se pored corona virusa desi da se inficiraju i sa jos 1 ili 2 virusa (gripom...), pa to izazove jos neke simptome (u smislu curenja nosa).

 

- Malo je pricao i o inficiranima bez simptoma. Kaze da niko nije nazvao te ljude par dana posle testiranja i anamneze da proveri da im se u medjuvremenu nisu pojavili neki blazi simptomi. On je bio ukljucen u pracenje prvih slucajeva u Nemackoj (u Bavarskoj, kada su se radnici jedne firme inficirali na nekom sastanku/proslavi na kojoj je bila neka Kineskinja iz Shangaja), pa su tada, par dana kasnije, ponovo nazvali par ljudi bez simptoma i pitali ih jos jednom o simptomima, a neki su im rekli da su imali neke male nelagodnosti, ali da ih nisu uzeli za ozbiljno. Tako da nije siguran koliko zaista ima asimptomaticnih pacijenata (onih koji nikada do kraja bolesti nemaju nekakve simptome), a koliko su neke, koji su u statistiku uvedeni kao asimpomaticni, zaprvo detektovali pre pojave blazih simptoma.

 

- Nisu mogli da nadju korelaciju izmedju koncentracije virusa u grlu i tezine toka bolesti (kao sto je slucaj kod nekih drugih bolesti). Mada kada se uporedi prosecna vrednost koncentracije virusa u grlu onih koji generalno imaju tezi tok bolesti s onom za inficirane s laksim tokom bolesti, ovi prvi u proseku imaju vecu koncentraciju (ali su preklapanja pojedinacnh vrednosti za dve grupe isuvise velika, kako sam shvatila, te ne mogu na osnovu prostog ocitavanja koncentracije virusa u grlu na pocetku bolesti da predvide da ce pacijent i stvarno imati tezi tok bolesti).

 

- Pitali ga o tome da li oni koji preleze bolest imaju trajne posledice na plucima. Kaze da onima koji izadju iz bolnice treba dugo vremena da se generalno oporave, cak mesec dana potom se generalno osecaju slabo, kao i da funkcija pluca nije bas dobra (kod teskih slucajeva).

 

- Pitali ga o saradnji s drigim istrazivacima, van Nemacke. Kaze da postoji, prvenstveno u Evropi (saradnja je podrzana od EU). Medjutim sada su svi u frci oko ove krize i primorani da se skoncentrisu na fazu bolesti koja je aktuelna u njihovoj zemlji. Rekao je da je i u Kini bila takva frka te naucnici nisu imali vremena da se pozabave detaljima i pisu radove, sto tek sada cine, kad se situacija smirila.

- Pricao je i o konkurenciji za finansiranje medju naucnicima, kao i o problemu da pare dobiju oni koji su se specijalizovali za pisanje predloga projekata, a ne oni s najboljim predlozima za istrazivanje (i jos par "problemcica" iz naucnog sveta).

- Pitali ga o naucnicima iz istocne Evrope, da li oni rade na resenju za corona virus. Kaze da je generalno bolest u istocnoj Evropi par koraka iza zapadne Evrope, da je nauka u istocnoj Evropi slabo finansirana pa su mnogi (inace odllicni naucnici) napustili nauku i bave se necim drugim da bi mogli da zarade za zivot, kao i da je zdravstvo generalno u losijem stanju nego na zapadu.

 

Eto, to je ukratko danasnji podcast. Mozda vam je bilo zanimljivo da procitate.

[𝓑𝓪𝓫𝔂]

Da li postoji neka analiza o vakcinisanima protiv sezonske gripe i obolelima od coronavirusa? 

 

[handys]

5 hours ago, wwww said:

l

Eto, to je ukratko danasnji podcast. Mozda vam je bilo zanimljivo da procitate.

 

Hvala na trudu i vremenu! To je verovatno najbolji izvor informacija na koji sam naisao. Zanima me, a izvini ako je bilo vec, da li je pricao o tome kako neke postojece vakcine, recimo za grip ili pneumokok uticu na imunitet protiv ovog virusa? Negde sam video da neki nemacki i holandski lekari veruju da su oni koji su primili pneumokoknu vakcinu u boljem polozaju, mada naravno daleko od toga da su sigurni.

[wwww]

4 hours ago, handys said:

 

Hvala na trudu i vremenu! To je verovatno najbolji izvor informacija na koji sam naisao. Zanima me, a izvini ako je bilo vec, da li je pricao o tome kako neke postojece vakcine, recimo za grip ili pneumokok uticu na imunitet protiv ovog virusa? Negde sam video da neki nemacki i holandski lekari veruju da su oni koji su primili pneumokoknu vakcinu u boljem polozaju, mada naravno daleko od toga da su sigurni.

Nema na cemu.

Ja sam slusala jednog drugog lekara u nekoj tv emisiji koji je pre neke 2-3 sedmice (cini mi se) preporucio vakcinu protiv pneumokoka kao sredstvo koje mozda nece direktno uticati na corona virus, ali moze da spreci da se paralelno razviju i druge infekcije koje ce dodatno oslabiti sanse da organizam dobro odgovori na corona virus.

Takodje je bila neka reportaza o univerzitetu u Utrechtu koji pocinje studiju o uticaju vakcine protiv tuberkuloze. Smatraju da ce ovim da se podigne opsti imunitet orgnizma (tvrde da je ovo poznat efekt), sto ce onda da pomogne u borbi protiv corona virusa.

 

Evo sad sam nasla kad je govorio o tome (nisam tu epizodu slusala ranije jer sam se kasnije ukljucila): 10.3. Transkript je ovde: https://www.ndr.de/nachrichten/info/10-Coronavirus-Update-Grossveranstaltungen-absagen,podcastcoronavirus124.html

google prevod:

Quote

Q: whether and how useful a pneumococcal vaccination would still be?

Drosten: Yes, we know that this viral disease is getting worse, especially in patients over 65 years, 70 or 80 years, with the mortality rates among those infected. That's why you have to think about what you can do for additional protection. And with influenza, it is notorious for the virus to come and go quickly. But it leaves a trail of devastation and confusion in the lungs in the cytokine pattern of immune cells. So the immune cells in the lungs are completely messed up by this virus, and then bacteria can take over. These are often bacteria from our own throat that sit there all the time. Pneumococci, for example, are among the most common, and they then have free rein. Otherwise they are kept in check by the immune system in the throat. And then, once this influenza virus has passed over the mucous membranes and passed through the lungs, these bacteria can get into our lungs from our throat. Then they get a classic pneumonia. Most patients die from influenza infection. You can now vaccinate against them, that's pneumococcal vaccination. It is logical to say that although this is not an influenza virus now, it is also a virus that grows in the lungs. And every virus messes up the immune system there. Again, it will be worthwhile to have a pneumococcal vaccine to prevent at least this complication, these secondary or over-infections by pneumococci. That is the general and correct reasoning behind it.
Pneumococcal vaccination continues to make sense

And then as a scientist who deals specifically with the disease, I have to add one thing. Unfortunately I have to pour some water into the wine. According to the case reports that we now know, pneumococcal over-infections in this disease are not as common as in influenza. However, it is not harmful to do this vaccination if you want to protect yourself against eventualities. If you want to protect yourself from getting an over-infection that will always exist, just not as often as with the flu. Then you should get vaccinated, and that is why you should do it especially with the older groups of people. Pneumococcal vaccination is recommended for them anyway.

 

Quote

Q: What about a quick vaccination against influenza, that is, against the flu? Brings what?

Drosten: The influenza season is still going on, but it will end in the next few weeks. We have an influenza vaccination two weeks before the general population has an influenza vaccine, so it really comes to an end. But the next influenza season is coming, the pandemic will still be there in the next influenza season. And that is why it is now worth taking a flu vaccination with you again and especially refreshing it next fall. Because then, from now and next autumn, you will have a particularly good protection against influenza in the coming, simultaneous influenza and SARS-2 infection wave next year at this time.

Q: And that actually applies to the entire population, not just to the elderly with influenza?

Drosten: That applies to the entire population. But here too we have clear indication groups for influenza vaccination. One can say that these are also older people from retirement age. And there are additional indication groups. There are certain risk groups, but also pregnant women. We have already talked about how fortunately the pregnant women are not particularly at risk in this disease.

 

 

 

Edited March 28, 2020 by wwww

[Asterion]

11 hours ago, Asterion said:

 

First known cat infected with coronavirus reported in Belgium

 

 

 

A cat in Belgian has tested positive for the coronavirus after catching the potentially deadly bug from an infected owner, officials said Friday.

The sick pet in Liège tested positive after showing classic symptoms of COVID-19 — including difficulty breathing — a week after its owner first fell sick, health officials told a press conference, the Brussels Times reports.

While it is the first known infection of a cat, two dogs in Hong Kong have previously tested positive — with the first, a 17-year-old Pomeranian, dying after returning home from quarantine.

“The cat had diarrhea, kept vomiting and had breathing difficulties. The researchers found the virus in the cat’s feces,” professor Steven Van Gucht said Friday, according to the outlet.

No information was given on the conditions of either the cat or its owner, the Brussels Times said.

Meanwhile, the World Health Organization insists that there is “no evidence that a dog, cat or any pet can transmit COVID-19” to humans.

Van Gucht also stressed that the Liège case appeared to be the owner getting her pet sick.

 

“We want to stress that this is an isolated case,” he said, according to the Belgian newspaper. “The risk of animal-to-human transmission is very small.”

Belgium’s National Council for Animal Protection (CNPA) also told the paper that there is no known threat from pets.

“Animals are not vectors of the epidemic, so there is no reason to abandon your animal,” the agency said — while advising owners to “not rub their nose against their pets.”

As well as the cat, 7,284 people have been confirmed infected with coronavirus in Belgium, with almost 300 deaths, officials also said at the press conference.

 

izvor

 

Jel neko slučajno naletijo na neko studiju/istraživanje o recimo prisutnosti Covid-19 kod mačaka, pasa?

Jel zna neko koliko je npr. u Lombardiji broj mačaka ili pasa na 1 osobu u odnosu na ostale regije u Italiji li EU?

 

Dali je neko otkrijo asimptomatske pse, mačke?

 

 

Edited March 28, 2020 by Asterion

[Asterion]

 

[ciao]

Evo i kratak izvestaj iz Fra od nase zvezde Dr Raoult-a : on je sinoc podneo izvestaj o novom ispitivanju detaljnom nad 80 pacijenata, rezultat je da su 78 ozdravili, jedan umro (86 godina) i jedan se jos leci. To su neke cifre koje nisu mnogo razlicite od ranijih tj bez lecenja sa klorokin-om plus antibiotik medjutim postoji jedna bitna razlika koju je on naveo jos ranije a sada definitivno potvrdjeno - to je da kod ovih koji su ozdravili ozdravljenje ide bitno brze u odnosu na one koji su ozdravili bez ovog tretmana; Bez klorokina pacijentima treba nekih 20 dana da se oporave (oni koji se oporave)a ovi koji uzimaju terapiju Rault-ovu se oporave za 5-6 dana, posle 7-8  dana niko od njih nije imao nikakve tragove virusa; To je naravno bitno da jer se tako brze oslobadjaju mesta u bolnicama; Takodje je rekao da ne funkcionise ako se udje u kasnu fazu, otprilike onima kojima su vec potrebni respiratori klorikin ne moze da pomogne i ubrza izlecenje

Edited March 28, 2020 by ciao

[Asterion]

 

[riviera]

Spoiler

 

Quote

A Heart Attack? No, It Was the Coronavirus

Cardiologists are seeing infected patients whose worst symptoms are not respiratory, but cardiac.

 

Spoiler

The 64-year-old patient arrived at a hospital in Brooklyn with symptoms looking like those seen in patients having a serious heart attack.

An electrocardiogram revealed an ominous heart rhythm. The patient had high blood levels of a protein called troponin, a sign of damaged heart muscle. Doctors rushed to open the patient’s blocked arteries — but found that no arteries were blocked.

The patient was not having a heart attack. The culprit was the coronavirus.

The Brooklyn patient recovered after 12 days in the hospital and is now at home. But there have been reports of similar patients in the United States and abroad, and the cases have raised troubling questions for doctors.

What should doctors do these days when they see patients with apparent heart attacks? Should they first rule out coronavirus infection — or is that a waste of valuable time for the majority of patients who are actually having heart attacks?

 

Should every coronavirus patient be tested for high blood levels of troponin to see if the virus has attacked the heart?

“I don’t know what the right answer is,” said Dr. Nir Uriel, a cardiologist at Columbia University and Weill Cornell Medicine in New York.

The Brooklyn patient had myocarditis, an inflammation of the heart that has been seen in patients with other viral infections, such as MERS — also caused by a coronavirus — and the H1N1 swine flu.

But the new coronavirus, called SARS-CoV-2, mostly infects the lungs, causing pneumonia in severe cases. Believing it caused respiratory disease, many cardiologists thought the coronavirus was outside their specialty.

“We were thinking lungs, lungs, lungs — with us in a supportive role,” said Dr. John Rumsfeld, chief science and quality officer at the American College of Cardiology. “Then all of a sudden we began to hear about potential direct impact on the heart.”

A report on heart problems among coronavirus patients in Wuhan, China, was published in JAMA Cardiology on Friday.

The study, led by Dr. Zhibing Lu at Zhongnan Hospital of Wuhan University, found that 20 percent of patients hospitalized with Covid-19, the illness caused by the coronavirus, had some evidence of heart damage.

Many were not known to have underlying heart disease. But they often had abnormal electrocardiograms, like the patient in Brooklyn, in addition to elevated troponin levels, which sometimes soared to levels seen in patients with heart attacks.

The risk of death was more than four times higher among these patients, compared with patients without heart complications.

The journal also published a report, by doctors in Italy, describing a previously healthy 53-year-old woman who developed myocarditis.

 

Like the patient in Brooklyn, her electrocardiogram was abnormal, and she had high levels of troponin in her blood. Because of the coronavirus outbreak in Italy, doctors thought to test her and found she was infected.

 

 

 

Image

A 53-year-old Italian patient’s electrocardiogram showed signs suggesting a heart attack and no pneumonia.Credit...Inciardi RM et al., JAMA Cardiology, 2020

Dr. Enrico Ammirati, an expert in myocarditis at Niguarda Hospital in Milan who consulted on the case, said the patient’s heart problems were likely caused by her body’s immune response to the virus.

But so much about this new pathogen is unknown, and it is not yet clear what might cause heart damage following infection.

“Myocarditis can likely be caused either by the virus itself, or the body’s immune and inflammatory response to the virus,” said Dr. Scott Solomon, a cardiologist at Harvard Medical School.

Infected patients who get myocarditis do not necessarily have any more virus in their bodies than those who do not develop the condition, he said.

It is possible — but not yet established — that myocarditis results from an immune system that lurches out of control while trying to turn back the coronavirus, pumping out such excessive levels of chemicals called cytokines that cause inflammation that they damage the lungs and the heart alike.

The condition, called a cytokine storm, is more serious in older people and in people with underlying chronic diseases, Dr. Solomon said. It is the primary reason for the severe respiratory complications that can lead to death in patients with the coronavirus.

Cytokines also promote blood coagulation and interfere with the body’s clot-busting system, said Dr. Peter Libby, a cardiologist at Harvard Medical School. Blood clots in coronary arteries can block blood flow and cause heart attacks.

Another possibility, Dr. Libby said, is that some coronavirus patients develop heart problems as a consequence of infections in their lungs.

“The lungs are not working, so there is not enough oxygen,” he said. “That increases the risk for arrhythmias.”

At the same time, fever caused by the virus increases the body’s metabolism and the heart’s output of blood. The result is that the patient’s heart must struggle with an increased demand for oxygen but a reduced supply, an imbalance that may lead to heart damage.

But doctors cannot rule out the possibility that the coronavirus directly damages the heart, several experts said.

In Seattle, a patient infected with the virus recently died after experiencing so-called heart block: The electrical signals originating in the top of the organ, which sets the heart’s normal rhythm, were not reaching the bottom of the heart.

When that happens, the heart goes into an emergency mode with so-called escape rhythm, which causes it to beat very slowly. The man had underlying lung disease, which worsened his prognosis.

Dr. April S. Stempien-Otero, a cardiologist at the University of Washington, hopes an autopsy will show whether the virus attacked the man’s heart.

“We thought it was older-person heart block,” she said. “Then all of a sudden Covid raises its head.”

From now on, she said, “we have to think, maybe that is what is going on.”

 

 

 

 

Edited March 28, 2020 by riviera

[Asterion]

 

[Zvezdarac]

12 hours ago, wwww said:

 

- Misli da se corona previse rasirila i da nece u jednom trenutku samo nestati, vec da ce se, posle dostizanja 60-70% zarazenih i smirenja pandemije, ostatak naroda postepeno zaraziti i prelezati ga. (sto ce reci: ne mozemo umaci coroni)

 

 

 

 

 

A sta je poneta taktike karantina onda?Da se pregura ovaj prvi udar i onda da se ceka vakcina sl god.Ako se npr ove god zarazilo i prelezalo 10% stanovnisva i nekako se karantinom suzbije trenutna epidemija a procenat onih koji su imuni ostane relativno mali,to znaci da sledeci udar za par meseci bez da se vakcinise celokupno stanovnistvo nece biti nista slabiji.

Edited March 28, 2020 by Zvezdarac

[Mama_mia]

tacno sam znala da ce neki shia svestenik da detektuje kako je doslo do corona pandemije

 

i evo ga vec danas:

 

Yaghoub Fazeli, Al Arabiya

Saturday 28 March 2020

 

Iraqi Shia political leader Muqtada al-Sadr blamed the legalization of same-sex marriage for causing the coronavirus pandemic.

“One of the most appalling things that have caused this epidemic is the legalization of same-sex marriage,” al-Sadr said in a post on his Twitter account on Saturday.

“Hence, I call on all governments to repeal this law immediately and without any hesitation,” he added.

[zakkturbo]

https://www.bosch.com/stories/vivalytic-rapid-test-for-covid-19/

 

 

 

 

[Clash]

1 hour ago, Mama_mia said:

tacno sam znala da ce neki shia svestenik da detektuje kako je doslo do corona pandemije

 

i evo ga vec danas:

 

Yaghoub Fazeli, Al Arabiya

Saturday 28 March 2020

 

Iraqi Shia political leader Muqtada al-Sadr blamed the legalization of same-sex marriage for causing the coronavirus pandemic.

“One of the most appalling things that have caused this epidemic is the legalization of same-sex marriage,” al-Sadr said in a post on his Twitter account on Saturday.

“Hence, I call on all governments to repeal this law immediately and without any hesitation,” he added.

Koliko kasne, kad smo mi znali da je za poplave kriva LGBT parada.

[Pristevac]

3 minutes ago, CLakiSH said:

Koliko kasne, kad smo mi znali da je za poplave kriva LGBT parada.

Pokazuje rezultate testiranja od 2 do 2,5h

[Prijatelj Mitar]

Meflokvin?

 

Znam koliko su (nisu) RT i Sputnik pouzdani izvori, ali vidim da se spominje i nadlezna Federalna medicinsko-bioloska agencija. 

[Clash]

Iskace mi na twiteru da Oxford trazi zdrave dobrovoljce od 18-55 godina za testiranje vakcine. Oni su valjda nasli i vakcini za Mers. @Honey Badger znas li nesto vise?

[Baros]

18 minutes ago, Laki21 koji lebdi said:

Meflokvin?

 

Znam koliko su (nisu) RT i Sputnik pouzdani izvori, ali vidim da se spominje i nadlezna Federalna medicinsko-bioloska agencija. 

 

35 minutes ago, Baros said:

 

http://fmbaros.ru/press-tsentr/novosti/detail/?ELEMENT_ID=38052

 

[...]

13 minutes ago, CLakiSH said:

Iskace mi na twiteru da Oxford trazi zdrave dobrovoljce od 18-55 godina za testiranje vakcine. Oni su valjda nasli i vakcini za Mers. @Honey Badger znas li nesto vise?

 

Nemam pojma o tome, do mene nije doslo.

 

Ja pratim Guardian, BBC i londonski Evening Standard ali to kod njih nisam vidio. Kad izguglam Oxford Vaccine, izadje mi Oxford Mail, prilicni shite od websajta i par sajtova iz Indije. Mumbai Mirror i Times of India. Znam za Times of India, oni su legit, ali slabo je pokriveno pa ne znam sta bih ti rekao.

 

Taman i da je to istinita vijest, sto je sasvim moguce, ne vjerujem da ce imati problema nahvatati dobrovoljce.

Edited March 28, 2020 by Honey Badger

[kalistenika u rutini]

 

[Clash]

 

[...]

5 minutes ago, CLakiSH said:

 

 

Legit je. Mogao bih se i ja prijaviti, ispunjavam sve uslove.

 

https://covid19vaccinetrial.web.ox.ac.uk/volunteer

 

 

Edit: izgleda da London ne spada u Thames Valley Area, tako da ne mogu se prijaviti da volontiram.

 

 

Edited March 28, 2020 by Honey Badger

[Prijatelj Mitar]

Professor Adrian Hill, Director of the Jenner Institute at the University of Oxford, said, “The Oxford team had exceptional experience of a rapid vaccine response, such as to the Ebola outbreak in West Africa in 2014. This is an even greater challenge. Vaccines are being designed from scratch and progressed at an unprecedented rate. The upcoming trial will be critical for assessing the feasibility of vaccination against COVID-19 and could lead to early deployment.”