Epidemija koronavirusa (Covid-19 / SARS-Cov2) - dnevne aktuelnosti iz zemlje i sveta

[Sunshine State]

I JA nema bustere jos...

[McLeod]

Sto se tice "superspreder" eventova gde su skoro svi asimptomatski, trebalo bi konacno posle dve jebene godine odraditi eksperiment i testirati grupu ljudi kao kontrolnu cisto da konacno vidimo koliko je PCR pouzdan. Sve ove predikcije i "potentnost" Omikrona vrlo moguce leze u PCR testu.

 

[erwin]

 

 

 

 

Edited December 8, 2021 by erwin

[Clash]

Moderacijo, aj neko novo glasanje odje. Moramo raditi update našeg istraživanja, ne mogu stari podaci doveka.

Nešto tipa jeste li preležali, jeste li se bustovali, smislite nešto, nismo vas džaba birali za šerife.

@Eddard

[Sunshine State]

1 hour ago, Clash said:

Moderacijo, aj neko novo glasanje odje. Moramo raditi update našeg istraživanja, ne mogu stari podaci doveka.

Nešto tipa jeste li preležali, jeste li se bustovali, smislite nešto, nismo vas džaba birali za šerife.

@Eddard

 

Koji ce nam ocin, kad cemo svi pomreti od omicrona - i bustovani i nebustovani i prelezali i neprelezali!

 

Bilo mi je drago druziti se s vama!

 

(Ko je vas poznavao, ni pakao mu nece tesko pasti!) 

[Clash]

2 minutes ago, Sunshine State said:

 

Koji ce nam ocin, kad cemo svi pomreti od omicrona - i bustovani i nebustovani i prelezali i neprelezali!

 

Bilo mi je drago druziti se s vama!

 

(Ko je vas poznavao, ni pakao mu nece tesko pasti!) 

Ono jes, neki  cete izginete a neki koji su primili dva Sputnjika i bustovali Fajzerom na Novom Naselje u nedelju posle podne, ne znam tacno koji datum ce i da prezive.

[Sunshine State]

27 minutes ago, Clash said:

Ono jes, neki  cete izginete a neki koji su primili dva Sputnjika i bustovali Fajzerom na Novom Naselje u nedelju posle podne, ne znam tacno koji datum ce i da prezive.

 

Sad kad ti erwin izvuce neki graf gde se vidi da je kod 78.345 % takvih izraslo trece uvo na nosu!

[erwin]

Fajzer i Biontek kažu da 3 doze neutrališu, 2 i dalje verovatno štite od teških oblika bolesti.

 

Quote

PFIZER AND BIONTECH PROVIDE UPDATE ON OMICRON VARIANT
Wednesday, December 08, 2021 - 06:54am

- Preliminary laboratory studies demonstrate that three doses of the Pfizer-BioNTech COVID-19 Vaccine neutralize the Omicron variant (B.1.1.529 lineage) while two doses show significantly reduced neutralization titers
- Data indicate that a third dose of BNT162b2 increases the neutralizing antibody titers by 25-fold compared to two doses against the Omicron variant; titers after the booster dose are comparable to titers observed after two doses against the wild-type virus which are associated with high levels of protection
- As 80% of epitopes in the spike protein recognized by CD8+ T cells are not affected by the mutations in the Omicron variant, two doses may still induce protection against severe disease
- The companies continue to advance the development of a variant-specific vaccine for Omicron and expect to have it available by March in the event that an adaption is needed to further increase the level and duration of protection – with no change expected to the companies’ four billion dose capacity for 2022

NEW YORK & MAINZ, Germany--(BUSINESS WIRE)-- Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today announced results from an initial laboratory study demonstrating that serum antibodies induced by the Pfizer-BioNTech COVID-19 Vaccine (BNT162b2) neutralize the SARS-CoV-2 Omicron variant after three doses. Sera obtained from vaccinees one month after receiving the booster vaccination (third dose of BNT162b2 vaccine) neutralized the Omicron variant to levels that are comparable to thoseobserved for the wild-type SARS-CoV-2 spike protein after two doses.

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20211208005542/en/

Sera from individuals who received two doses of the current COVID-19 vaccine did exhibit, on average, more than a 25-fold reduction in neutralization titers against the Omicron variant compared to wild-type, indicating that two doses of BNT162b2 may not be sufficient to protect against infection with the Omicron variant. However, as the vast majority of epitopes targeted by vaccine-induced T cells are not affected by the mutations in Omicron, the companies believe that vaccinated individuals may still be protected against severe forms of the disease and are closely monitoring real world effectiveness against Omicron, globally.

A more robust protection may be achieved by a third dose as data from additional studies of the companies indicate that a booster with the current COVID-19 vaccine from Pfizer and BioNTech increases the antibody titers by 25-fold. According to the companies’ preliminary data, a third dose provides a similar level of neutralizing antibodies to Omicron as is observed after two doses against wild-type and other variants that emerged before Omicron. These antibody levels are associated with high efficacy against both the wild-type virus and these variants. A third dose also strongly increases CD8+ T cell levels against multiple spike protein epitopes which are considered to correlate with the protection against severe disease. Compared to the wild-type virus, the vast majority of these epitopes remain unchanged in the Omicron spike variant.

“Although two doses of the vaccine may still offer protection against severe disease caused by the Omicron strain, it’s clear from these preliminary data that protection is improved with a third dose of our vaccine,” said Albert Bourla, Chairman and Chief Executive Officer, Pfizer. “Ensuring as many people as possible are fully vaccinated with the first two dose series and a booster remains the best course of action to prevent the spread of COVID-19.”

“Our preliminary, first dataset indicate that a third dose could still offer a sufficient level of protection from disease of any severity caused by the Omicron variant,” said Ugur Sahin, M.D., CEO and Co-Founder of BioNTech. “Broad vaccination and booster campaigns around the world could help us to better protect people everywhere and to get through the winter season. We continue to work on an adapted vaccine which, we believe, will help to induce a high level of protection against Omicron-induced COVID-19 disease as well as a prolonged protection compared to the current vaccine.”

While these results are preliminary, the companies will continue to collect more laboratory data and evaluate real-world effectiveness to assess and confirm protection against Omicron and inform the most effective path forward. On November 25, the companies started to develop an Omicron-specific COVID-19 vaccine. The development will continue as planned in the event that a vaccine adaption is needed to increase the level and duration of protection against Omicron. First batches of the Omicron-based vaccine can be produced and are planned to be ready for deliveries within 100 days, pending regulatory approval. Pfizer and BioNTech have tested other variant-specific vaccines as well, which have produced very strong neutralization titers and a tolerable safety profile. Based on this experience the companies have high confidence that if needed they can deliver an Omicron-based vaccine in March 2022. The companies have also previously initiated clinical trials with variant-specific vaccines (Alpha, Beta, Delta & Alpha/Delta Mix) and data from these studies will be submitted to regulatory agencies around the world to help accelerate the process of adapting the vaccine and gaining regulatory authorization or approval of an Omicron-specific vaccine, if needed. The companies have previously announced that they expect to produce four billion doses of BNT162b2 in 2022, and this capacity is not expected to change if an adapted vaccine is required.

About the Pfizer-BioNTech Laboratory Studies

To evaluate the effectiveness of BNT162b2 against the Omicron variant, Pfizer and BioNTech immediately tested a panel of human immune sera obtained from the blood of individuals that received two or three 30-µg doses of the current Pfizer-BioNTech COVID-19 vaccine, using a pseudovirus neutralization test (pVNT The sera were collected from subjects 3 weeks after receiving the second dose or one month after receiving the third dose of the Pfizer-BioNTech COVID-19 vaccine. Each serum was tested simultaneously for its neutralizing antibody titer against the wild-type SARS-Cov-2 spike protein, and the Omicron spike variant. The third dose significantly increased the neutralizing antibody titers against the Omicron strain spike by 25-fold. Neutralization against the Omicron variant after three doses of the Pfizer-BioNTech COVID-19 vaccine was comparable to the neutralization against the wild-type strain observed in sera from individuals who received two doses of the companies’ COVID-19 vaccine: The geometric mean titer (GMT) of neutralizing antibody against the Omicron variant measured in the samples was 154 (after three doses), compared to 398 against the Delta variant (after three doses) and 155 against the ancestral strain (after two doses). Data on the persistence of neutralizing titers over time after a booster dose of BNT162b2 against the Omicron variant will be collected.

The Pfizer-BioNTech COVID-19 vaccine, which is based on BioNTech’s proprietary mRNA technology, was developed by both BioNTech and Pfizer. BioNTech is the Marketing Authorization Holder in the United States, the European Union, the United Kingdom, Canada and other countries and the holder of emergency use authorizations or equivalents in the United States (jointly with Pfizer) and other countries. Submissions to pursue regulatory approvals in those countries where emergency use authorizations or equivalent were initially granted are planned.

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-provide-update-omicron-variant

[ciao]

Procitah ovaj tekst, malo po dijagonali sto bi ovde rekli, poveci je, ali nisam videla da pise koliko dugo stite ove tri doze? dve nedelje? sest meseci? ne zna se ?

[erwin]

Piše da su testirali mesec dana od treće, čisto sumnjam da nisu testirali i uzorke onih koji su buster primili ranije (pre 2 ili 3 meseca) pa došli do nepovoljnijih rezultata koje ne bi hteli da objave.

 

I uglavnom, uvek ću pre verovati nezavisnim ispitivanjima nego onima koje obavljaju sami proizvođači, a onda saopštavaju samo one rezultate koji im odgovaraju.

Edited December 8, 2021 by erwin

[40Wins]

2 hours ago, Sunshine State said:

 

Koji ce nam ocin, kad cemo svi pomreti od omicrona - i bustovani i nebustovani i prelezali i neprelezali!

 

Bilo mi je drago druziti se s vama!

 

(Ko je vas poznavao, ni pakao mu nece tesko pasti!) 

 

Znaci da bi bio siguran od omikronare, treba da si prelezao, sto skorije i sto teze po mogucstvu + 2 doze Fajzera i buster Sinofarm, pa nakon 3 meseca Sputnjik, i onda si DOBAR. 

[Sunshine State]

2 minutes ago, AgroLaki said:

 

Znaci da bi bio siguran od omikronare, treba da si prelezao, sto skorije i sto teze po mogucstvu + 2 doze Fajzera i buster Sinofarm, pa nakon 3 meseca Sputnjik, i onda si DOBAR. 

 

Ne! I onda si zarazen, ali asimptomatican!

[ciao]

i to narednih mesec dana !

[Kronostime]

23 minutes ago, Sunshine State said:

 

Ne! I onda si zarazen, ali asimptomatican!

 

7 minutes ago, ciao said:

i to narednih mesec dana !

[40Wins]

Gazda sta bi sa tobom? @Kronostime

[Kronostime]

Just now, AgroLaki said:

Gazda sta bi sa tobom? @Kronostime

Negativan na testu.

Sad, da li je bila neka upala ili sam asimptomatican, bemliga.

[𝓑𝓪𝓫𝔂]

36 minutes ago, Kronostime said:

Negativan na testu.

Sad, da li je bila neka upala ili sam asimptomatican, bemliga.

 

Verovatno da nisi simptomatican jer bi test bio pozitivan. Verovatno si nesto drugo zakacio. 

[Sunshine State]

On 12/6/2021 at 4:36 PM, Sunshine State said:

Samo briga!

 

Sad mi mama javlja da prijateljicin sin (47 god, dva Sinopharma, buster Pfizer) od prekjuce ima temperaturu, danas isao kod lekara, CRP 201 (!), i upala pluca (rendgen), a antigen negativan (PCR rezultat sutra); ostaje u bolnici.

 

Mama i ta prijateljica svaki dan piju kafu zajedno.... juce su bile zajedno.... sad valja iscekati nekoliko dana da vidimo sta ce biti 😞

 

Update:

 

Juce dobio PCR, negativan, "upala pluca se povukla, CRP spada", danas ide kuci kako su mu rekli "da se ne bi razboleo u bolnici"

 

Ja ne mogu da verujem da coveku, uz onakav rezultat urina i CRPod 200, ne dijagnostikuju urinarnu infekciju, vec ga strpaju u bolnicu u "narandzastu zonu" (mogucnost zarazavanja tamo) i onda zakljuce da se infekcija smiruje uz antibiotike! Alooo, pa naravno, kad je bila bakterijska infekcija!

 

[Clash]

48 minutes ago, Kronostime said:

Negativan na testu.

Sad, da li je bila neka upala ili sam asimptomatican, bemliga.

Dali ti falš nalaz, ko bi tebe trpio u bolnici, neće ljudi da rizikuju.

[urosg3]

1 hour ago, Kronostime said:

Negativan na testu.

Sad, da li je bila neka upala ili sam asimptomatican, bemliga.

antipatičan 🙂

[zoe Bg]

1675/15618/41

 

Na respiratoru 194

 

U bolnicama 3304

[Stiletto]

2 hours ago, Kronostime said:

Negativan na testu.

Sad, da li je bila neka upala ili sam asimptomatican, bemliga.

 

Ma pala muva na medveda... 😁

[vilhelmina]

U Svedskoj, s izuzetkom par slabije naseljenih regiona, jos uvek nista od trece doze za nas omladince i omladinke ispod 65. Od juce kao vratili neke preporuke, rad od kuce i maske u javnom prevozu, i to je to. Broj zarazenih nizak, ali i do testova se tesko dolazi, tako da nije bas verovati statistici.

U nedostatku trece doze, moj poslodavac nam danas ponudio besplatnu vakcinu protiv sezonskog gripa, pa sam se bocnula. Isto boli ruka i udara u glavu, pa se sad pitam sta mi je to trebalo, ali rekoh daj sta das 😀.

[Prijatelj Mitar]

2 hours ago, Clash said:

Dali ti falš nalaz, ko bi tebe trpio u bolnici, neće ljudi da rizikuju.

 

Pustao bi svima na odeljenju Zikinu dinastiju 24/7 🙂

[Sunshine State]

3 minutes ago, vilhelmina said:

U Svedskoj, s izuzetkom par slabije naseljenih regiona, jos uvek nista od trece doze za nas omladince i omladinke ispod 65. Od juce kao vratili neke preporuke, rad od kuce i maske u javnom prevozu, i to je to. Broj zarazenih nizak, ali i do testova se tesko dolazi, tako da nije bas verovati statistici.

U nedostatku trece doze, moj poslodavac nam danas ponudio besplatnu vakcinu protiv sezonskog gripa, pa sam se bocnula. Isto boli ruka i udara u glavu, pa se sad pitam sta mi je to trebalo, ali rekoh daj sta das 😀.

 

I u Holandijji broj testiranja smanjen, ali to je zato sto vlada traži od ljudi da idu u GGD (zdravstvene ustanove/test) samo ako imaju simptome i prvo su uradili samotestiranje sa pozitivnim rezultatom ili ako im se simptomi pogoršaju.