Epidemija koronavirusa (Covid-19 / SARS-Cov2) - dnevne aktuelnosti iz zemlje i sveta

[Sunshine State]

Ovo dole i ima smisla, ali antibiotici?!

 

MHRA approves Xevudy (sotrovimab), a COVID-19 treatment found to cut hospitalisation and death by 79%

 

Another COVID-19 treatment, Xevudy (sotrovimab), has today been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) after it was found to be safe and effective at reducing the risk of hospitalisation and death in people with mild to moderate COVID-19 infection who are at an increased risk of developing severe disease.

 

In a clinical trial, a single dose of the monoclonal antibody was found to reduce the risk of hospitalisation and death by 79% in high-risk adults with symptomatic COVID-19 infection.

[Sunshine State]

Za razliku od srpskih "covid ambulanti, krvi, rendgena, antibiotika i 14 dana karantina", Niskozemci krecu ovako:

 

"On Friday, the Health Ministry will change its guidelines to the public about what to do when early symptoms of the coronavirus infection arise. People with symptoms that suggest an infection of the SARS-CoV-2 coronavirus should first take a self-test to check whether they are infected.

They do not have to remain home if the result is negative. With a positive result, they should stay home except to visit a local branch of the GGD municipal health service for a second test to confirm the initial result. Up until now, the advice was to always visit the GGD for a test if experiencing coronavirus-like symptoms.

If the complaints persist, it is recommended to do a follow-up self-test one day later. When symptoms last longer, or when they get worse, people are still strongly advised to go to the GGD."

 

Prevod:

 

Ministarstvo zdravlja će u petak promeniti smernice javnosti o tome šta da rade kada se jave rani simptomi zaraze korona virusom. Ljudi sa simptomima koji ukazuju na infekciju koronavirusom SARS-CoV-2 prvo bi trebalo da se podvrgnu samotestiranju kako bi proverili da li su zaraženi.

Ne moraju da ostanu kod kuće ako je rezultat negativan. Sa pozitivnim rezultatom, trebalo bi da ostanu kod kuće, osim da posete lokalnu filijalu opštinske zdravstvene službe GGD radi drugog testa kako bi potvrdili početni rezultat. Do sada je savet bio da uvek posetite GGD radi testiranja ako imate simptome slične koronavirusu.

Ako tegobe i dalje postoje, preporučuje se da se jedan dan kasnije uradi naknadni samotest. Kada simptomi traju duže ili kada se pogoršaju, ljudima se i dalje preporučuje da odu u GGD (Opštinske zdravstvene službe).

[urosg3]

4 minutes ago, Sunshine State said:

Za razliku od srpskih "covid ambulanti, krvi, rendgena, antibiotika i 14 dana karantina", Niskozemci krecu ovako:

 

"On Friday, the Health Ministry will change its guidelines to the public about what to do when early symptoms of the coronavirus infection arise. People with symptoms that suggest an infection of the SARS-CoV-2 coronavirus should first take a self-test to check whether they are infected.

They do not have to remain home if the result is negative. With a positive result, they should stay home except to visit a local branch of the GGD municipal health service for a second test to confirm the initial result. Up until now, the advice was to always visit the GGD for a test if experiencing coronavirus-like symptoms.

If the complaints persist, it is recommended to do a follow-up self-test one day later. When symptoms last longer, or when they get worse, people are still strongly advised to go to the GGD."

 

Prevod:

 

Ministarstvo zdravlja će u petak promeniti smernice javnosti o tome šta da rade kada se jave rani simptomi zaraze korona virusom. Ljudi sa simptomima koji ukazuju na infekciju koronavirusom SARS-CoV-2 prvo bi trebalo da se podvrgnu samotestiranju kako bi proverili da li su zaraženi.

Ne moraju da ostanu kod kuće ako je rezultat negativan. Sa pozitivnim rezultatom, trebalo bi da ostanu kod kuće, osim da posete lokalnu filijalu opštinske zdravstvene službe GGD radi drugog testa kako bi potvrdili početni rezultat. Do sada je savet bio da uvek posetite GGD radi testiranja ako imate simptome slične koronavirusu.

Ako tegobe i dalje postoje, preporučuje se da se jedan dan kasnije uradi naknadni samotest. Kada simptomi traju duže ili kada se pogoršaju, ljudima se i dalje preporučuje da odu u GGD (Opštinske zdravstvene službe).

Zato im i ide kako im ide. Worldometer ne laže 🙂
Nigde nema etičke dimenzije, ne sukobljavaju društvene i starosne grupe, ne ucenjuju nikoga, krajnje razumno i logično.


 

[Cyber]

Krajnje je vreme da neko prelomi - nadam se da ce Bundestag da dâ zeleno svetlo za obaveznu vakcinaciju od februara.

Do tada nevakcicnisani imaju priliku da se vakcinisu - fer.

Hut ab, Deutschland! 👍

 

Spoiler

Kappa dole!

 

 

Edited December 2, 2021 by Cyber

[Tomiprunet]

2 minutes ago, Cyber said:

Krajnje je vreme da neko prelomi - nadam se da ce Bundestag da dâ zeleno svetlo za obaveznu vakcinaciju od 1. februara.

Hut ab, Deutschland! 👍

 

  Hide contents

Kappa dole!

 

 

I ja se nadam, jedino mi nije jasno zasto svi idu od 1. Februara? Zasto ne cim sto pre

[Sunshine State]

Zar nije Austrija vec odlucila?

[Sunshine State]

17 minutes ago, urosg3 said:

Zato im i ide kako im ide. Worldometer ne laže 🙂
Nigde nema etičke dimenzije, ne sukobljavaju društvene i starosne grupe, ne ucenjuju nikoga, krajnje razumno i logično.


 

 

Oni, cak i sa svojim relativno nonsalantnim pristupom (pisali vec - sedi kuci i cekaj da prodje), imaju 200 umrlih manje na milion stanovnika nego "covid ambulanta - rendgen - antibiotik" drzava (a svi znamo da su zvanicne brojke umrlih u "antibiotik" drzavi jos vece nego zvanicno prijavljene)

[Cyber]

8 minutes ago, Sunshine State said:

Zar nije Austrija vec odlucila?

 

Da, lapsus calami - trebalo je da  stoji "jos neko". 

[Sunshine State]

2 minutes ago, Cyber said:

 

Da, lapsus calami - trebalo je da  stoji "jos neko". 

 

Ako i Nemacka uvede, garant ce i NL i Belgija.

 

Kakva je situacija sa skandinavskim zemljama, sto se toga tice?

[urosg3]

8 minutes ago, Sunshine State said:

 

Oni, cak i sa svojim relativno nonsalantnim pristupom (pisali vec - sedi kuci i cekaj da prodje), imaju 200 umrlih manje na milion stanovnika nego "covid ambulanta - rendgen - antibiotik" drzava (a svi znamo da su zvanicne brojke umrlih u "antibiotik" drzavi jos vece nego zvanicno prijavljene)

Pa kažem ja worldometer ne laže. Ovde doktor mora da prepiše terapiju, pa linčovali bi ga da čekaš nekoliko sati a ne dobiješ ni rendgen ni antibiotik, pa šta si čekao onda

[Cyber]

2 minutes ago, Sunshine State said:

 

Ako i Nemacka uvede, garant ce i NL i Belgija.

 

Kakva je situacija sa skandinavskim zemljama, sto se toga tice?

 

Ma kakvi, ni u najavi. Ovo su drugi svetovi.

Spoiler

Hipotetcki, ali vrlo hipoteticki i nategnuto, ako bi neko bio kadar pod uslovom da dogovri - to su Danci. 

 

[urosg3]

28 minutes ago, Cyber said:

Krajnje je vreme da neko prelomi - nadam se da ce Bundestag da dâ zeleno svetlo za obaveznu vakcinaciju od februara.

Do tada nevakcicnisani imaju priliku da se vakcinisu - fer.

Hut ab, Deutschland! 👍

 

  Reveal hidden contents

Kappa dole!

 

 

Ti nemci umesto da se premišljaju do 1. Februara mogli bi malo da nekom kampanjom disciplinuju razbarušene dojčere, pa da ih malo poduče da valja da nose maske i da to za 53% sprečava dalje infekcije (ima istaživanje majkemi) i na taj način smanje pritisak na zdravstveni sistem.
Razumem ja i nedisciplinu i nepoverenje prema vlastima ali struka i lekari preporučuju osim vakcine da se nosi maska, šta im teško?

kako mi ide 🙂

[Cyber]

Just now, urosg3 said:

Ti nemci umesto da se premišljaju do 1. Februara mogli bi malo da nekom kampanjom disciplinuju razbarušene dojčere, pa da ih malo poduče da valja da nose maske i da to za 53% sprečava dalje infekcije (ima istaživanje majkemi) i na taj način smanje pritisak na zdravstveni sistem.
Razumem ja i nedisciplinu i nepoverenje prema vlastima ali struka i lekari preporučuju osim vakcine da se nosi maska, šta im teško?

kako mi ide 🙂

 

Kako god da ti ide, mislim da Nemcima ide bolje.  😉

Ko nije vakcinisan - ne može više da se švrćka kako hoće medju vakcinisanim svetom.

[Sunshine State]

9 minutes ago, urosg3 said:

Ti nemci umesto da se premišljaju do 1. Februara mogli bi malo da nekom kampanjom disciplinuju razbarušene dojčere, pa da ih malo poduče da valja da nose maske i da to za 53% sprečava dalje infekcije (ima istaživanje majkemi) i na taj način smanje pritisak na zdravstveni sistem.
Razumem ja i nedisciplinu i nepoverenje prema vlastima ali struka i lekari preporučuju osim vakcine da se nosi maska, šta im teško?

kako mi ide 🙂

 

Piskaramo ovde vec skoro dve godine, a ne secam se da li sam ikad procitala/pitala zasto ti toliko smetaju maske? (mozda cak i vise nego sto Slavisi smeta Pfizer 😄 )

 

Nije da sam bas nesto luda bez maski, ali juce doleteh, nosila masku bez prestanka 17 sati - ne mogu da kazem da sam uzivala, ali skoro da mi nije ni smetalo.

 

Masku u prodavnici (ono, 15-20 minuta) ni ne primetim....na Floridi nije obavezna za vakcinisane, ali ja ni u jednu prodavnicu nisam usla bez maske - nije mi tesko, cak i da je skroz beskorisno - a nije....postedi od silnih "mirisa" 😄

[urosg3]

7 minutes ago, Sunshine State said:

 

Piskaramo ovde vec skoro dve godine, a ne secam se da li sam ikad procitala/pitala zasto ti toliko smetaju maske? (mozda cak i vise nego sto Slavisi smeta Pfizer 😄 )

 

Nije da sam bas nesto luda bez maski, ali juce doleteh, nosila masku bez prestanka 17 sati - ne mogu da kazem da sam uzivala, ali skoro da mi nije ni smetalo.

 

Masku u prodavnici (ono, 15-20 minuta) ni ne primetim....na Floridi nije obavezna za vakcinisane, ali ja ni u jednu prodavnicu nisam usla bez maske - nije mi tesko, cak i da je skroz beskorisno - a nije....postedi od silnih "mirisa" 😄

Mislio sam da to napišem na kraju, da ne kvarimo merak, u mom text editoru (inače uvek Vi nikad emacs) stoji taj podugački tekst, ima dosta unazad, ali držim ga na hladnom i mračnom - neće da se ukvari 🙂

A i mislim da je prigodan tekst za kraj, ako ga ikad bude. A sa druge strane ako pravimo onu žurku na Kosmaju sa prasetom, pevanjem i ritualnim spaljivanjem maski ima da ga pročitam naglas i tečno.

[40Wins]

 

2 hours ago, Eddard said:

  

 

  

 

Kad sam ja bio bolestan cuo se sa nekim bivsim kolegom, ali 10 godina stariji od mene, ozbiljan covek, kaze, jel si uzeo Hemomicin, odmah uzmi hemomicin NEMOJ DA SE ZEZAS. I jos 2 lika znam da cim su dobili simptome odma uzeli Hemomicin preko veze. 

[Tomiprunet]

 
Kako god da ti ide, mislim da Nemcima ide bolje.  [emoji6]
Ko nije vakcinisan - ne može više da se švrćka kako hoće medju vakcinisanim svetom.

Samo nek se vakcinisani svrckaju dok ne stigne omikron

[Džudi]

 

8 hours ago, AgroLaki said:

 

Jbg, tek danas je otisao da uradi CRP i D dimer privatno, pa ce videti da li ima i bakt. infekciju. Kevi su odmah dali antibiotike, jer je njoj bilo izrazito crveno grlo. Makar piju nolpazu i probiotike, meni tast nije hteo nista sem antibiotika da pije, da se ne truje.  (Posle ga usaravila dijareja)

 

Nolpaza, ali pre svega probiotici su jako važni kada se piju antibiotici. Želim da ti se i mama i tata oporave što pre..

[erwin]

 

Spoiler

 

 

 

 

 

 

 

 

 

 

[Romantik]

9 hours ago, Sunshine State said:

 

Piskaramo ovde vec skoro dve godine, a ne secam se da li sam ikad procitala/pitala zasto ti toliko smetaju maske? (mozda cak i vise nego sto Slavisi smeta Pfizer 😄 )

 

Nije da sam bas nesto luda bez maski, ali juce doleteh, nosila masku bez prestanka 17 sati - ne mogu da kazem da sam uzivala, ali skoro da mi nije ni smetalo.

 

Masku u prodavnici (ono, 15-20 minuta) ni ne primetim....na Floridi nije obavezna za vakcinisane, ali ja ni u jednu prodavnicu nisam usla bez maske - nije mi tesko, cak i da je skroz beskorisno - a nije....postedi od silnih "mirisa" 😄

 

Jeste da je Urosu namenjeno, ali...stvar i maski i vakcina je sto ugrozavaju licni komfor na koji smo navikli i menjaju zivot nagore a bez da doprinose tebi licno vec to radis zbog drugih, logicno da ce ici otpor, nesto dajes a ne dobijas nista zauzvrat.

Masku da bi stavio negde kad ulazis moras da je imas kod sebe. Za zene to mozda i nije toliki probelm jer nose torbe, pa mogu u njima imati i maske, za mene je to ogroman problem jer em moram voditi racuna da je stalno nosim sa sobom, plus sto maska mora biti u dzepu, a samim tim mora i u nekoj kesi, jer nije higijenski drzati je dzepu, a i ovako ne ispadne higijenski uvek, i normalno da ces imati otpor da stavljas na usta nesto sto nije besprekorno cisto. Dalje, ja zimi napolju ne mogu da budem ni 30-ak sekundi bez trake (oko glave, umesto kape), ja to nosim cim je temperatura manja od 10-ak stepeni, sa maskom ja moram da skinem traku pre ulaska u zatvoreni prostor da bih mogao staviti masku, a zatim istu mogu staviti tek po izlasku iz prostorije, a pre su obe radnje radjene iskljucivo u zatvorenom prostoru, sto ce reci ja sad izlazim napolje bez trake, zbog cega sam prehladjen jos cesce nego uobicajeno, jer kao sto rekoh ekstremno sam osetljiv na bilo koji oblik hladnoce. I tako da bih ispostovao mere i stitio druge ja vec godinu i po stetim svojm zdravlju, kako onda ne biti protiv toga?

[nemanjaol]

Vidjao sam ljude da nose pamučne maske  koje se "kace" iza glave, a ne oko usiju.

 

I to bas imaju lastis, ne moraju da se vezuju.  Pronadjes to i resio si problem

[Tomiprunet]

Mene jedino smara maska zimi, jer mi se zamagle naocale 

[Prijatelj Mitar]

 

Znaci, koliko sam razumeo, u "hramu srpske medicine" za prethodnih godinu dana je preminulo oko 4000 osoba, odnosno cetvrtina hospitalizovanih pacijenata?

[Eddard]

3 hours ago, Romantik said:

 

Jeste da je Urosu namenjeno, ali...stvar i maski i vakcina je sto ugrozavaju licni komfor na koji smo navikli i menjaju zivot nagore a bez da doprinose tebi licno vec to radis zbog drugih, logicno da ce ici otpor, nesto dajes a ne dobijas nista zauzvrat.

 

Kako misliš vakcina ne doprinosi tebi lično? Nego kome?

[erwin]

Nature objavio odličan pregled trenutnih saznanja o omikronu sa izjavama gomile vrlo relevantnih naučnika, potvrđuje dosta toga što je već kačeno i dodaje nove informacije i objašnjenja:

 

Quote

How bad is Omicron? What scientists know so far

COVID researchers are working at breakneck speed to learn about the variant’s transmissibility, severity and ability to evade vaccines.

Barely a week has elapsed since scientists in Botswana and South Africa alerted the world to a fast-spreading new  SARS-CoV-2 variant now known as Omicron . Researchers worldwide are racing to understand the threat that the variant — now confirmed in more than 20 countries — poses to the world. Yet it might take scientists weeks to paint a more complete picture of Omicron, and to gain an understanding of its transmissibility and severity, as well as its potential to evade vaccines and cause reinfections.

“Wherever I go, everyone says: tell us more about Omicron,” says Senjuti Saha, molecular microbiologist and director of the Child Health Research Foundation in Dacca, Bangladesh. “There is so little understanding of what’s going on, and that’s true, even for scientists.”

Nature rounds up what scientists know so far about the Omicron variant.

 

How fast is Omicron spreading?
Omicron’s rapid rise in South Africa is what worries researchers most, because it suggests the variant could spark explosive increases in COVID-19 cases elsewhere. On 1 December, South Africa recorded 8,561 cases, up from the 3,402 reported on 26 November and several hundred per day in mid-November, with much of the growth occurring in Gauteng Province, home to Johannesburg.

Epidemiologists measure an epidemic’s growth using R, the average number of new cases spread by each infection. In late November, South Africa’s National Institute for Communicable Disease (NICD) in Johannesburg determined that R was above 2 in Gauteng. That level of growth was last observed in the early days of the pandemic, Richard Lessels, an infectious-disease physician at KwaZulu-Natal University in Durban, South Africa, told a press briefing last week.

Gauteng’s R value was well below 1 in September — when Delta was the predominant variant and cases were falling — suggesting that Omicron has the potential to spread much faster and infect vastly more people than Delta, says Tom Wenseleers, an evolutionary biologist at KU-Leuven in Belgium. Based on the rise in COVID-19 cases and sequencing data, Wenseleers estimates that Omicron can infect 3 to 6 times as many people as Delta, over the same time period. “That’s a huge advantage for the virus — but not for us,” he adds.

Researchers will be watching how Omicron spreads in other parts of South Africa and globally to get a better read on its transmissibility, says Christian Althaus, a computational epidemiologist at the University of Bern, Switzerland. Heightened surveillance in South Africa could cause researchers to overestimate Omicron’s fast growth. But if this pattern is repeated in other countries, it’s very strong evidence that Omicron has a transmission advantage, adds Althaus. “If it doesn’t happen, for example, in European countries, it means things are a bit more complex and strongly depend on the immunological landscape. So we have to wait.”

Although genome sequencing is needed to confirm Omicron cases, some PCR tests can pick up a hallmark of the variant that distinguishes it from Delta. On the basis of this signal, there are preliminary signs that cases, although extremely low in number, are rising in the United Kingdom. “That’s certainly not what we want to see right now and suggests that Omicron could indeed also have a transmission advantage in the UK,” Althaus adds.

 

Can Omicron overcome immunity from vaccines or infection?
The variant’s swift rise in South Africa hints that it has some capacity to overcome immunity. Around one-quarter of South Africans are fully vaccinated, and it’s likely that a large fraction of the population was infected with SARS-CoV-2 in earlier waves, says Wenseleers, based on heightened death rates since the start of the pandemic.

In this context, Omicron’s success in southern Africa might be due largely to its capacity to infect people who recovered from cases of COVID-19 caused by Delta and other variants, as well as those who’ve been vaccinated. A  2 December preprint from researchers at the NICD  found that reinfections in South Africa have increased, as Omicron has spread. “Unfortunately, this is the perfect environment for immune escape variants to develop,” says Althaus.

How well the variant spreads elsewhere might depend on factors such as vaccination and prior infection rates, says Aris Katzourakis, an expert in viral evolution at the University of Oxford, UK. “If you throw it into the mix in a highly vaccinated population that has given up on other control measures, it might have the edge there.”

Researchers want to measure Omicron’s ability to evade immune responses and the protection they offer. For instance, a team led by Penny Moore, a virologist at the NICD and the University of Witwatersrand in Johannesburg, is measuring the ability of neutralizing, or virus-blocking, antibodies triggered by previous infection and vaccination to stop Omicron from infecting cells, in a laboratory test. Her team is making ‘pseudovirus’ particles — an engineered version of HIV that uses SARS-CoV-2’s spike protein to infect cells — to match Omicron, which harbours as many as 32 changes to spike.

Another South Africa-based team, led by virologist Alex Sigal at the African Health Research Institute in Durban, is conducting similar tests on virus-neutralizing antibodies using infectious SARS-CoV-2 particles. So is a team led by Pei-Yong Shi, a virologist at the University of Texas Medical Branch in Galveston, who is collaborating with Pfizer–BioNtech to determine how its vaccine holds up against Omicron. “I was really very concerned when I saw the constellation of mutations in the spike,” he says. “We just have to wait for the results.”

Previous studies of Omicron’s spike mutations — particularly in the region that recognizes receptors on human cells — suggest that the variant will blunt the potency of neutralizing antibodies. For instance, in a September 2021 Nature paper, a team co-led by Paul Bieniasz, a virologist at Rockefeller University in New York City, engineered a highly mutated version of spike — in a virus incapable of causing COVID-19 — that shares numerous mutations with Omicron. The ‘polymutant spike’ proved fully resistant to neutralizing antibodies from most of the people they tested who had either received two doses of an RNA vaccine or recovered from COVID-19. With Omicron, “we expect there to be a significant hit,” says Bieniasz.

 

How will vaccines fare against Omicron?
If Omicron can dodge neutralizing antibodies, it does not mean that immune responses triggered by vaccination and prior infection will offer no protection against the variant. Immunity studies suggest that relatively low levels of neutralizing antibodies may protect people from severe forms of COVID-19, says Miles Davenport, an immunologist at the University of New South Wales in Sydney, Australia.

Other parts of the immune system, particularly T cells, may be less affected by Omicron’s mutations than are antibody responses. Researchers in South Africa plan to measure the activity of T cells and another immune player called natural killer cells, which may be especially important for protection against severe COVID-19, says Shabir Madhi, a vaccinologist at the University of Witwatersrand.

Madhi, who has led COVID-19 vaccine trials in South Africa, is also part of efforts to conduct epidemiological studies of vaccines’ effectiveness against Omicron. There are anecdotal reports of breakthrough infections in all three vaccines that have been administered in South Africa – Johnson & Johnson, Pfizer–BioNtech and Oxford–AstraZeneca. But Madhi says researchers will want to quantify the level of protection provided by vaccines, as well as prior infection against Omicron.

He suspects that the results will be reminiscent of how the AstraZeneca–Oxford vaccine performed against the Beta variant, an immune-evading variant that was identified in South Africa in late 2020. A study led by Madhi found that the vaccine offered little protection against mild and moderate cases in relatively young people, while a real-world analysis in Canada showed greater than 80% protection against hospitalization.

If Omicron behaves similarly, Madhi says, “we’re going to see a surge of cases. We’re going to see lots of breakthrough infections, lots of reinfections. But there’s going to be this unhinging of the case rate in the community compared to the hospitalization rate”. Early reports suggest that most breakthrough infections with Omicron have been mild, says Madhi. “For me, that is a positive signal.”

 

Will current boosters improve protection against Omicron?
The threat of Omicron has prompted some rich countries, such as the United Kingdom, to accelerate and broaden the roll-out of COVID vaccine booster doses. But it’s not yet clear how effective these additional doses will be.

Third doses supercharge neutralizing-antibody levels, and it’s likely that this will provide a bulwark against Omicron’s ability to evade these antibodies, says Bieniasz. His team’s work on the polymutant spike found that people who had recovered from COVID-19 months before receiving their jabs had antibodies still capable of blocking the mutant spike. To Bieniasz, those results suggest that people with repeated exposure to SARS-CoV-2’s spike protein, be it through infection or a booster dose, are “quite likely to have neutralizing activity against Omicron.”

 

Does Omicron cause milder or more severe disease than previous variants?
Early reports linked Omicron with mild disease, raising hopes that the variant might be less severe than some of its predecessors. But these reports — which are often based on anecdotes or scant scraps of data — can be misleading, cautions Müge Çevik, an infectious disease specialist at the University of St Andrews, UK. “Everyone is trying to find some data that could guide us,” she says. “But it’s very difficult at the moment.”

A major challenge when assessing whether a variant’s severity is controlling for the many confounding variables that can influence the course of disease, particularly when outbreaks are geographically localized. For example, reports of mild disease from Omicron infection in South Africa could reflect the fact that the country has a relatively young population, many of whom have already been exposed to SARS-CoV-2.

During the early days of the Delta outbreak, there were reports that the variant was causing more serious illness in children than other variants — an association that dissolved once more data were collected, Çevik says.

Researchers will be looking for data on Omicron infections in other countries. This geographical spread, and a larger sample size as cases accrue, will give researchers a better idea of how generalizable the early anecdotes might be. Ultimately, researchers will want to conduct case-controlled studies in which the demographics of people infected with Omicron are carefully matched to the demographics of a comparison group. This will allow scientists to better control for important factors, such as age, vaccination status and health conditions. Data from both groups will need to be collected contemporaneously, because the number of hospitalizations can be influenced by overall hospital capacity in a region.

And, crucially, researchers will need to control for the level of economic deprivation. A rapidly spreading new variant may reach vulnerable groups more rapidly, Çevik says, by nature of their work or living conditions. And such groups often experience more severe disease.

All of this will take time. “I think the severity question will be one of the last bits that we’ll be able to untangle,” she says. “That’s how it happened with Delta.”

 

Where has Omicron spread and how are scientists tracking it?
So far, Omicron has been detected in more than 20 countries, a number that has been steadily ticking up as efforts to track the variant increase around the world.

But the capacity to rapidly sequence viruses from positive COVID tests is concentrated in wealthy countries, meaning that early data on Omicron’s spread will be skewed.

Surveillance efforts in Brazil and some other countries are taking advantage of a distinctive result on particular PCR tests for COVID that could allow them to pinpoint potential Omicron cases for sequencing, says virologist Renato Santana at the Federal University of Minas Gerais in Brazil. The test looks for segments of three viral genes, one of which is the gene that encodes for the spike protein. Mutations in Omicron’s spike gene prevent its detection in the test, meaning that samples containing the variant will only test positive for two of the genes.

Even so, not everyone uses that kit and it could take some time before Omicron’s spread is fully mapped. Despite some guidelines urging countries to sequence 5% of their samples that test positive for SARS-CoV-2, few countries can afford to do so, says computational virologist Anderson Brito at the All for Health Institute in São Paulo, Brazil. And Brito worries that the travel bans some countries enacted against South Africa and other southern African nations in the wake of its Omicron discovery could discourage governments from sharing their surveillance data. “We are punishing those who did a good job,” he says.

In Bangladesh, which sequences about 0.2% of positive coronavirus samples, researchers would be eager to ramp up genomic surveillance to monitor for Omicron and other emerging variants, says molecular microbiologist Senjuti Saha, a molecular microbiologist and director of the Child Health Research Foundation in Dhaka. But resources are limited. Bangladesh is recovering from a large dengue outbreak, she adds. “In the Global South, we are all worried about COVID, but let’s not forget our endemic diseases,” Saha says. “We can only do so many.”

https://www.nature.com/articles/d41586-021-03614-z

Edited December 3, 2021 by erwin