Sunshine State

Postavih ranije neki link koji su nam juce slali, da ce sve vezano za COVID-19 biti fast track, nece ici redovnim, najcesce dugogodisnjim procedurama. S jedne strane treba naci vakcinu, lek, testirati da je efikasno, a s druge osigurati da nije stetno....nece sutra, svakako - plasim se da cemo pre doci do herd immunity, nego do approved vakcine/leka, koja je "potvrdjena" ( by McLeod)

Bold - nek si nam i kaz'o! Mi, inace, ne znamo, nego iz dosade i radoznalosti prenosimo ono u sta i malo strucniji od nas nisu sigurni. Ja radim na jedno klinickoj studiji vec 5-u godinu, pa jos se ne moze sa sigurnocu potvrditi niti da nema serious adverse effects, niti da je efikasan toliko da ga treba odobriti,.... a ne da ocekujem da, u jeku nepoznatog virusa, bilo ko na svetu ima POTVRDJENE podatke, terapije, etc za taj isti virus.... Bold: To je vec stvar drzave - ne mozes u Nemackoj opustositi apoteku, ako je lek na recept, taman da se svaki minut vrti na svim medijima da taj lek leci coronu.

Ne postoji approved lek/tretman za COVID-19, kao sto svi znamo.... ovo sto se daje/pokusava je vise empirijski, na osnovu tretmana slicnih virusa Postoje neka saznanja na osnovu dosadasnjih slucajeva, i mora se od neceg krenuti, npr. laboratorijski nalazi koji mogu da ukazuju na COVID-19: Laboratory findings — In patients with COVID-19, the white blood cell count can vary. Leukopenia, leukocytosis, and lymphopenia have been reported, although lymphopenia appears most common [23,37-39]. Elevated lactate dehydrogenase and ferritin levels are common, and elevated aminotransferase levels have also been described. On admission, many patients with pneumonia have normal serum procalcitonin levels; however, in those requiring intensive care unit (ICU) care, they are more likely to be elevated . High D-dimer levels and more severe lymphopenia have been associated with mortality. Certain investigational agents have been described in observational series or are being used anecdotally based on in vitro or extrapolated evidence. It is important to acknowledge that there are no controlled data supporting the use of any of these agents, and their efficacy for COVID-19 is unknown. ●Remdesivir – Several randomized trials are underway to evaluate the efficacy of remdesivir for moderate or severe COVID-19 [71]. Remdesivir is a novel nucleotide analogue that has activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and related coronaviruses (including SARS and MERS-CoV) both in vitro and in animal studies [72,73]. The compassionate use of remdesivir through an investigational new drug application was described in a case report of one of the first patients with COVID-19 in the United States [74]. Any clinical impact of remdesivir on COVID-19 remains unknown. ●Chloroquine/hydroxychloroquine – Both chloroquine and hydroxychloroquine inhibit SARS-CoV-2 in vitro, although hydroxychloroquine appears to have more potent antiviral activity [75]. A number of clinical trials are underway in China to evaluate the use of chloroquine or hydroxychloroquine for COVID-19 [76]. ●Lopinavir-ritonavir – This combined protease inhibitor, which has primarily been used for HIV infection, has in vitro activity against the SARS-CoV [77] and appears to have some activity against MERS-CoV in animal studies [78]. The use of this agent for treatment of COVID-19 has been described in case reports [79-81], but its efficacy is unclear. In one report of five patients who were treated with lopinavir-ritonavir, three improved and two had clinical deterioration; four had gastrointestinal side effects. It is being evaluated in larger randomized trials. ●Tocilizumab – Treatment guidelines from China's National Health Commission include the IL-6 inhibitor tocilizumab for patients with severe COVID-19 and elevated IL-6 levels; the agent is being evaluated in a clinical trial [82]. Other interventions of interest but with limited or no clinical data include interferon beta and convalescent serum.

GMO! Al' svet se vise boji GMO-a, nego corona virusa

Ne mogu da editujem moj poslednji post - vazno da dodam, za sve moje upise: radim u Drug Safety, Medical Affairs and Pharmacovigilance i vrlo dobro znam koliko je vremena, para i znanja potrebno da bi se bilo sta moglo tvrditi - pa ni onda nije "zapisano u kamenu" (hint: slucaj Vioxx), tako da sve ovo sto se sad radi i pokusava sa COVID-19 su upravo to, samo pokuaji, zasnovani na prethodnim saznanjima i iskustvima, sa slicnim virusima (SARS, MERS).

Ako se odnosilo na moj post - sorry, ne pricam o uzimanju lekova na svoju ruku Chloroqine, remdesivir, oseltamivir, lopinavir/ritonavir, tocilizumab, steroidi (methylprednisolone) su lekovi koji se daju u bolnicama, od strane lekara, nije paracetamol koji kupis OTC.

Pa nije na nivou belog luka -chloroquine je jedan od lekova u protocolu za tretman simptoma COVID-19, uz nekoliko '...vire" lekova i methylprednisolone-a

Sta ocekivati od "obicnog" sveta, kad su lekari KBC Rebra precutali da su isli na vikend u Austriju, vratili se na posao zarazeni i sad je 140 medicinskih radnika u izolaciji, "neupotrebljivi" za ono za cega su obuceni i placeni! 😞

Ako sve ovo prodje bez da Crnogorci imaju ijednog zarazenog, Mila odmah na celo WHO 😄

Stiglo nam juce, olaksace/ubrzace sve research koji su vezani za COVID-19: https://www.hra.nhs.uk/planning-and-improving-research/policies-standards-legislation/covid-19-guidance-sponsors-sites-and-researchers/ 1. New studies relating to COVID-19 An expedited review process is available for studies relating to COVID-19 where there are public health grounds for rapid review. The full process for fast-track reviews is set out in the Standard Operating Procedures for Research Ethics Committees.

Vrlo lepo objasnjen herd immunity i UK approach: Prof Matthew Baylis, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, said: “What is herd immunity? In a nutshell, everyone in a population is protected from infection before all of them are immune. The reason is that at a certain level of immunity (i.e., a proportion of people are immune, from having had the disease or having been vaccinated), the point comes when – on average – one infected person does not manage to contact and pass the infection on to one other person. Most of their contacts are already immune. The occasional contact is still susceptible, and the odd transmission event happens, but not often enough to sustain the disease. Transmission grinds to a halt, even though some or even many people have still not had the disease. This is herd immunity. It is one of the reasons boys are vaccinated against rubella: by vaccinating boys, boys are less likely to transmit to girls (an effect of immunity), and by vaccinating boys, girls are less likely to transmit to girls (an effect of herd immunity). For herd immunity, it does not matter whether the immunity comes from vaccination, or people having had the disease; people just need to be immune. “A key question is how much immunity is needed before we get herd immunity? It varies per disease, depending on how transmissible it is. For a highly transmissible disease, like measles, on average one person might infect up 20 others, and herd immunity kicks in at 95% immune – and so, the target coverage for MMR vaccine is 95%. For flu, on average one person infects just 1.3 others; in this case herd immunity kicks in at about 25% immune or less; and so the target coverage for flu vaccine is much less than it is for measles (three quarters of over 65s). “So what about COVID-19? Estimates are that one person may infect as many as 2-3 others, on average, meaning herd immunity should kick in at 50 – 67% of the population immune. And so in the absence of a vaccine, there would appear to be nothing to stop the spread of the virus until 50-67% of us have had it; and at that point herd immunity will kicks in and transmission will decline or stop. This is where the 60% of the population statistic has come from. And this is deeply concerning – taking the low fatality rate estimate of 1%, even 50% of the UK population infected by COVID-19 is an unthinkable level of mortality. “But it doesn’t have to be – and it won’t be – this way. By reducing the number of people that one person infects, on average, then we lower the point at which herd immunity kicks in. If we reduce it to 1.3, COVID19 becomes more like flu, and herd immunity kicks in when about one quarter of the population has had the disease and is now immune. So, from an epidemiological point of view, the trick is to reduce the number of people we are in contact with (by staying more at home), and reduce the chance of transmission to those we are in contact with (by frequent hand washing) so that we can drive down the number of contacts we infect, and herd immunity starts earlier. The sweet spot comes at the point where one infected person infects one, or less than one, person on average. But, importantly, we will need to sustain this until we have a vaccine: only at that point can we return to normal behaviour patterns, with herd immunity now achieved by vaccination, not disease.”

Stra'ota! https://m.youtube.com/watch?v=9-8zcBogaKY

Ovde u mom "malom mistu" divan, suncan dan - zasto ne dozvoliti starijim ljudima da prosetaju pola sata-sat napolju, ne u guzvi? Mi imamo divan kej, odrediti vreme, recimo 11-12 h kad starji ljudi mogu da izadju i prosetaju - sanse da se zaraze coronom setajuci po polupraznim ulicama, parkovima, kejovim, su manje nego da ih strefe slogovi sedeci u stanovima i ne krecuci se.

S onog worldometer site gde se prati brojka zarazenih-umrlih: 101,691 Seasonal flu deaths this year Quick facts: Every year an estimated 290,000 to 650,000 people die in the world due to complications from seasonal influenza (flu) viruses. This figure corresponds to 795 to 1,781 deaths per day due to the seasonal flu. Sources and info: Seasonal flu death estimate increases worldwide - CDC Up to 650 000 people die of respiratory diseases linked to seasonal flu each year - World Health Organization (WHO)

Ok, razmisljaj tako da je vecina u slicnoj situaciji, da i u Italiji, koja je pogodjena mnogo gore od nas, i dalje ima zdravih ljudi, uradi ono sto je u tvojoj moci glede prevencije, i to je to - ne vredi dramiti, paniciti...

Ja dosla 8. marta, redovna poseta, planirala da ostanem do 12.aprila, pa na Floridu. Sve otkazano, ostajem u Srbiji do daljnjeg - radim od kuce svakako (vec 10 godina), tako da mi je svejedno gde sedim zatvorena (ovde mi bar mama moze kuvati 🙂 ) Fitnes instruktorka ce nam drzati casove online! Mama shvatila ozbiljno, jer kaslje vec 2 meseca, izlazice u svoju basticu da se bavi cvecem, to je otprilike to

Imali sad neki sastanak i jedan Clinical Trial Manager rece da se peak u US ocekuje u julu 😞

Kreteni! Nemacka ima 4 puta vise zarazenih, a 14 umrlih i 2 u kriticnom stanju - NL 24 umrla i 45 u kriticnom stanju Doce im nonsalanacija glave - bukvalno!

Gledam brojke na brodu Diamond Princess - to bi trebalo, statisticki, da pokaze kakve bi brojke bile u slucaju (samo) izolacije, jer to je jedino "mesto" gde su mere izolacije krenule odmah i gde se izolacija striktno sprovodi. Jedino je diskutabilna starosna pripadnost, jer vecinu putnika na krstarenjima cini stariji svet. Diamond Princess 696 7 456 233 15

Jedno vreme je Nemacka bila ispred Spanije po broju zarazenih, da bi je Spanija odjednom pretekla - znaci da se nije vodilo racuna o sirenju zaraze

Ako je tacno da su jos u januaru nasli zarazene corona virusom, koje je objasnjenje sta se desilo sa sirenjem (zaustavljanjem) epidemije u US do pre 2 nedelje?

Na stranu tradicionalne teorije zavera, farmaceutske mafije i ostalo, ali neki strucnjaci tvrde slicno: " In the U.S. there are over 1,600 confirmed cases, according to the Centers for Disease Control and Prevention (CDC), with 41 deaths. Makary said that the number of cases, though, is likely much higher. “Don’t believe the numbers when you see, even on our Johns Hopkins website, that 1,600 Americans have the virus,” he said. “No, that means 1,600 got the test, tested positive. There are probably 25 to 50 people who have the virus for every one person who is confirmed.”

Gledam onaj worldometer - koliko se nista ne moze zakljuciti, cudo jedno! Broj zarazenih [Nemacka + Svedska + Danska] ~ Spanija Broj umrlih zajedno u ove 3 drzave = 12 Broj umrlih u Spaniji = 195 Broj serious/critical slucajeva zajedno u ove 3 drzave = 13 Broj serious/critical u Spaniji = 293

Moja prijateljica Holandjanka, lekar (hirurg i psihijatar) kaze mi sinoc kad sam je pitala kakve su im mere"naredili":"Government advised to cancel all meetings with more than 100 patients or health care workers ( they have to stay healthy to work)" Skole i dalje rade... Edit: univerziteti zatvoreni od ponedeljka, osnovne i srednje skole rade

Wow, skoro 3500 novih slucajeva u Italiji