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Juanito

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    Covid-19 / SARS-Cov2 - naučne/medicinske informacije i analize

    in Društvo

    Posted · Edited by Juanito

     

     

    Quote

    The majority of people infected with SARS-CoV-2 appear to actively shed infectious virus for about 8 days, but there is a wide range of variability from person to person. Understanding how long people can remain actively infected is important, because it provides new details about a disease and a virus that are still not well understood and informs public health decisions. Researchers report November 4 in the journal Cell an unusual case of one woman with leukemia and a low antibody count who was infected with the coronavirus for at least 105 days, and infectious for at least 70, while remaining asymptomatic the entire time.

     

     

    The patient, a 71-year-old woman, was immunocompromised due to chronic lymphocytic leukemia and acquired hypogammaglobulinemia. She never showed any symptoms of COVID-19. She was found to be infected with the virus when she was screened after being admitted to the hospital for severe anemia and her doctors recognized that she had been a resident of a rehabilitation facility experiencing a large outbreak.

    Munster's lab at NIAID's Rocky Mountain Laboratories in Hamilton, Montana, began studying samples that were regularly collected from the patient's upper respiratory tract. They found that infectious virus continued to be present for at least 70 days after the first positive test, and the woman didn't fully clear the virus until after day 105. "This was something that we expected might happen, but it had never been reported before," Munster says.

    The investigators believe the patient remained infectious for so long because her compromised immune system never allowed her to mount a response. Blood tests showed that her body was never able to make antibodies. At one point she was treated with convalescent plasma, but Munster doesn't think the treatment had an effect because of its low concentration of antibodies. Despite her inability to mount an antibody response, she never went on to develop COVID-19.

    The team performed deep sequencing on all the virus samples obtained from the patient to see how the virus might have changed over the course of the patient's infection. Samples collected at various times displayed different dominant gene variants. However, the investigators don't think that these mutations played a role in how long the virus persisted, because they saw no evidence of natural selection. Selection would have been implicated if one of the variants had appeared to provide the virus with a survival benefit and had become the dominant variant, but none of them did. They also tested whether or not the mutations affected the ability or speed of the virus to replicate and found no differences.

    Munster says that as far as he knows, this is the longest case of anyone being actively infect-ed with SARS-CoV-2 while remaining asymptomatic. "We've seen similar cases with influenza and with Middle East respiratory syndrome, which is also caused by a coronavirus," he notes. "We expect to see more reports like ours coming out in the future."

    etc

    Epidemija koronavirusa (Covid-19 / SARS-Cov2) - dnevne aktuelnosti iz zemlje i sveta

    in Društvo

    Posted

    9 minutes ago, Sunshine State said:

     

    "The number of people being treated in intensive care rose by 13 to 549 while 1,485 patients on regular wards are being treated for coronavirus, national patient coordination centre LCPS said."

     

    Danasnji podaci za NL - 1485 pacijenata na bolnickom lecenju, plus 549 u intenzivnoj.

    Otkud u Nemackoj 200 000 na lecenju? To je 100 puta vise nego u NL.....a Nemacka ima ca. 5 puta vise stanovnika. Nekako mi cudna tolika nesrazmera?!

     

    Broj pacijenata na respiratoru se vec uklapa (manje-vise) - u DE ih ima nekih 8 puta vise nego u NL.....ali ih nema 100 puta vise.



     

     

    Treba  ovako:

    - na lečenju zbog covida -> teži slučajevi

    - kad bi pustio virus da slobodno kreče kroz populaciju, ko bi od age groups bio sa teži posledicama? 65+ grupa

    - Znači treba pogledati/usporediti koliko su stari hospitalizirani pacienti DE, NL, ...etc.

    Verovatno se je virus u DE dobro raširio po staračkim  domovima.

    Kulinarstvo

    in Gastronomija

    Posted

    5 hours ago, Kronostime said:

    Usi, nogice i glava ti daju dovoljno pektina (zelatina) da se sve to lepo stegne.

    Ostalo je podesavanje ukusa.

    Kuvaj i cuti - svi ce probati.:s_d:

     

    Mali komentar...pektin se nalazi u biljkama.

     

     

    • Like 1

    Epidemija koronavirusa (Covid-19 / SARS-Cov2) - dnevne aktuelnosti iz zemlje i sveta

    in Društvo

    Posted

    33 minutes ago, Sunshine State said:

     

    Viber je prepiska, pa jedva nadjoh par poruka vezano za ivermectin:

     

    "Do 0,2mg/kg ili 12 mg ivermektina nedeljno, preventiva za rizicne grupe."

     

    "Ima ga u veterinarskim apotekama u obliku rastvora".

     

    Ne mogu da nadjem ostale, ima milion poruka u grupi

     

    Q: Should I take ivermectin to prevent or treat COVID-19?

    A: No. While there are approved uses for ivermectin in people and animals, it is not approved for the prevention or treatment of COVID-19. You should not take any medicine to treat or prevent COVID-19 unless it has been prescribed to you by your health care provider and acquired from a legitimate source. 

    A recently released research articleExternal Link Disclaimer described the effect of ivermectin on SARS-CoV-2 in a laboratory setting. These types of laboratory studies are commonly used at an early stage of drug development. Additional testing is needed to determine whether ivermectin might be appropriate to prevent or treat coronavirus or COVID-19.

     

    Q: Is there any danger to humans taking ivermectin? 

    A: There are approved uses for ivermectin in people and animals but it is not approved for the prevention or treatment of COVID-19. You should not take any medicine to treat or prevent COVID-19 unless it has been prescribed to you by your health care provider and acquired from a legitimate source.

    Some of the side-effects that may be associated with ivermectin include skin rash, nausea, vomiting, diarrhea, stomach pain, facial or limb swelling, neurologic adverse events (dizziness, seizures, confusion), sudden drop in blood pressure, severe skin rash potentially requiring hospitalization and liver injury (hepatitis). Laboratory test abnormalities include decrease in white cell count and elevated liver tests. Any use of ivermectin for the prevention or treatment of COVID-19 should be avoided as its benefits and safety for these purposes have not been established. Data from clinical trials are necessary for us to determine whether ivermectin is safe and effective in treating or preventing COVID-19.

     

    FDA

     

     

     

     

    Just now, Juanito said:

     

    Q: Should I take ivermectin to prevent or treat COVID-19?

    A: No. While there are approved uses for ivermectin in people and animals, it is not approved for the prevention or treatment of COVID-19. You should not take any medicine to treat or prevent COVID-19 unless it has been prescribed to you by your health care provider and acquired from a legitimate source. 

    A recently released research articleExternal Link Disclaimer described the effect of ivermectin on SARS-CoV-2 in a laboratory setting. These types of laboratory studies are commonly used at an early stage of drug development. Additional testing is needed to determine whether ivermectin might be appropriate to prevent or treat coronavirus or COVID-19.

     

    Q: Is there any danger to humans taking ivermectin? 

    A: There are approved uses for ivermectin in people and animals but it is not approved for the prevention or treatment of COVID-19. You should not take any medicine to treat or prevent COVID-19 unless it has been prescribed to you by your health care provider and acquired from a legitimate source.

    Some of the side-effects that may be associated with ivermectin include skin rash, nausea, vomiting, diarrhea, stomach pain, facial or limb swelling, neurologic adverse events (dizziness, seizures, confusion), sudden drop in blood pressure, severe skin rash potentially requiring hospitalization and liver injury (hepatitis). Laboratory test abnormalities include decrease in white cell count and elevated liver tests. Any use of ivermectin for the prevention or treatment of COVID-19 should be avoided as its benefits and safety for these purposes have not been established. Data from clinical trials are necessary for us to determine whether ivermectin is safe and effective in treating or preventing COVID-19.

     

    FDA

     

     

     

     

    Content current as of:

    12/16/2020

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